1kqq

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[[Image:1kqq.gif|left|200px]]
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{{Seed}}
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[[Image:1kqq.png|left|200px]]
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{{STRUCTURE_1kqq| PDB=1kqq | SCENE= }}
{{STRUCTURE_1kqq| PDB=1kqq | SCENE= }}
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'''Solution Structure of the Dead ringer ARID-DNA Complex'''
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===Solution Structure of the Dead ringer ARID-DNA Complex===
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==Overview==
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The AT-rich interaction domain (ARID) is a DNA-binding module found in many eukaryotic transcription factors. Using NMR spectroscopy, we have determined the first ever three-dimensional structure of an ARID--DNA complex (mol. wt 25.7 kDa) formed by Dead ringer from Drosophila melanogaster. ARIDs recognize DNA through a novel mechanism involving major groove immobilization of a large loop that connects the helices of a non-canonical helix-turn-helix motif, and through a concomitant structural rearrangement that produces stabilizing contacts from a beta-hairpin. Dead ringer's preference for AT-rich DNA originates from three positions within the ARID fold that form energetically significant contacts to an adenine-thymine base step. Amino acids that dictate binding specificity are not highly conserved, suggesting that ARIDs will bind to a range of nucleotide sequences. Extended ARIDs, found in several sequence-specific transcription factors, are distinguished by the presence of a C-terminal helix that may increase their intrinsic affinity for DNA. The prevalence of serine amino acids at all specificity determining positions suggests that ARIDs within SWI/SNF-related complexes will interact with DNA non-sequence specifically.
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The line below this paragraph, {{ABSTRACT_PUBMED_11867548}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11867548 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11867548}}
==About this Structure==
==About this Structure==
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1KQQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQQ OCA].
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1KQQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQQ OCA].
==Reference==
==Reference==
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[[Category: Arid]]
[[Category: Arid]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:03:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:47:37 2008''

Revision as of 07:47, 2 July 2008

Image:1kqq.png

Template:STRUCTURE 1kqq

Solution Structure of the Dead ringer ARID-DNA Complex

Template:ABSTRACT PUBMED 11867548

About this Structure

1KQQ is a Single protein structure of sequence from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

The structure of the Dead ringer-DNA complex reveals how AT-rich interaction domains (ARIDs) recognize DNA., Iwahara J, Iwahara M, Daughdrill GW, Ford J, Clubb RT, EMBO J. 2002 Mar 1;21(5):1197-209. PMID:11867548

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