1kr5

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{{STRUCTURE_1kr5| PDB=1kr5 | SCENE= }}
{{STRUCTURE_1kr5| PDB=1kr5 | SCENE= }}
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'''Crystal structure of human L-isoaspartyl methyltransferase'''
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===Crystal structure of human L-isoaspartyl methyltransferase===
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==Overview==
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The enzyme l-isoaspartyl methyltransferase initiates the repair of damaged proteins by recognizing and methylating isomerized and racemized aspartyl residues in aging proteins. The crystal structure of the human enzyme containing a bound S-adenosyl-l-homocysteine cofactor is reported here at a resolution of 2.1 A. A comparison of the human enzyme to homologs from two other species reveals several significant differences among otherwise similar structures. In all three structures, we find that three conserved charged residues are buried in the protein interior near the active site. Electrostatics calculations suggest that these buried charges might make significant contributions to the energetics of binding the charged S-adenosyl-l-methionine cofactor and to catalysis. We suggest a possible structural explanation for the observed differences in reactivity toward the structurally similar l-isoaspartyl and d-aspartyl residues in the human, archael, and eubacterial enzymes. Finally, the human structure reveals that the known genetic polymorphism at residue 119 (Val/Ile) maps to an exposed region away from the active site.
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The line below this paragraph, {{ABSTRACT_PUBMED_11792715}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11792715 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11792715}}
==About this Structure==
==About this Structure==
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[[Category: Yeates, T O.]]
[[Category: Yeates, T O.]]
[[Category: Rossmann-fold doubly-wound-alpha-beta-alpha-sandwich]]
[[Category: Rossmann-fold doubly-wound-alpha-beta-alpha-sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:04:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:49:18 2008''

Revision as of 07:49, 2 July 2008

Image:1kr5.png

Template:STRUCTURE 1kr5

Crystal structure of human L-isoaspartyl methyltransferase

Template:ABSTRACT PUBMED 11792715

About this Structure

1KR5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human L-isoaspartyl methyltransferase., Ryttersgaard C, Griffith SC, Sawaya MR, MacLaren DC, Clarke S, Yeates TO, J Biol Chem. 2002 Mar 22;277(12):10642-6. Epub 2002 Jan 15. PMID:11792715

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