1ksn

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[[Image:1ksn.gif|left|200px]]
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{{STRUCTURE_1ksn| PDB=1ksn | SCENE= }}
{{STRUCTURE_1ksn| PDB=1ksn | SCENE= }}
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'''Crystal Structure of Human Coagulation Factor XA Complexed with FXV673'''
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===Crystal Structure of Human Coagulation Factor XA Complexed with FXV673===
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==Overview==
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Further optimization of the beta-aminoester class of factor Xa (fXa) inhibitors is described culminating in the identification of 9c (FXV673), a potent and selective factor Xa inhibitor with excellent in vivo anticoagulant activity. An X-ray structure of FXV673 bound to human fXa is also presented. Based on its selectivity, potent in vivo activity and favorable pre-clinical safety profile, FXV673 was selected for further development and is currently undergoing clinical trials.
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(as it appears on PubMed at http://www.pubmed.gov), where 12039587 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12039587}}
==About this Structure==
==About this Structure==
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[[Category: Maignan, S.]]
[[Category: Maignan, S.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:07:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:54:44 2008''

Revision as of 07:54, 2 July 2008

Image:1ksn.png

Template:STRUCTURE 1ksn

Crystal Structure of Human Coagulation Factor XA Complexed with FXV673

Template:ABSTRACT PUBMED 12039587

About this Structure

1KSN is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Optimization of the beta-aminoester class of factor Xa inhibitors. Part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity., Guertin KR, Gardner CJ, Klein SI, Zulli AL, Czekaj M, Gong Y, Spada AP, Cheney DL, Maignan S, Guilloteau JP, Brown KD, Colussi DJ, Chu V, Heran CL, Morgan SR, Bentley RG, Dunwiddie CT, Leadley RJ, Pauls HW, Bioorg Med Chem Lett. 2002 Jun 17;12(12):1671-4. PMID:12039587

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