1ktg

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[[Image:1ktg.gif|left|200px]]
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{{STRUCTURE_1ktg| PDB=1ktg | SCENE= }}
{{STRUCTURE_1ktg| PDB=1ktg | SCENE= }}
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'''Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex'''
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===Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex===
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==Overview==
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The crystal structure of C. elegans Ap(4)A hydrolase has been determined for the free enzyme and a binary complex at 2.0 A and 1.8 A, respectively. Ap(4)A hydrolase has a key role in regulating the intracellular Ap(4)A levels and hence potentially the cellular response to metabolic stress and/or differentiation and apoptosis via the Ap(3)A/Ap(4)A ratio. The structures reveal that the enzyme has the mixed alpha/beta fold of the Nudix family and also show how the enzyme binds and locates its substrate with respect to the catalytic machinery of the Nudix motif. These results suggest how the enzyme can catalyze the hydrolysis of a range of related dinucleoside tetraphosphate, but not triphosphate, compounds through precise orientation of key elements of the substrate.
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(as it appears on PubMed at http://www.pubmed.gov), where 11937063 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11937063}}
==About this Structure==
==About this Structure==
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[[Category: Magnesium cluster]]
[[Category: Magnesium cluster]]
[[Category: Nudix]]
[[Category: Nudix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:09:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:57:52 2008''

Revision as of 07:57, 2 July 2008

Image:1ktg.png

Template:STRUCTURE 1ktg

Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex

Template:ABSTRACT PUBMED 11937063

About this Structure

1KTG is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms., Bailey S, Sedelnikova SE, Blackburn GM, Abdelghany HM, Baker PJ, McLennan AG, Rafferty JB, Structure. 2002 Apr;10(4):589-600. PMID:11937063

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