1ktj

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{{STRUCTURE_1ktj| PDB=1ktj | SCENE= }}
{{STRUCTURE_1ktj| PDB=1ktj | SCENE= }}
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'''X-ray Structure Of Der P 2, The Major House Dust Mite Allergen'''
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===X-ray Structure Of Der P 2, The Major House Dust Mite Allergen===
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==Overview==
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The crystal structure of the common house mite (Dermatophagoides sp.) Der p 2 allergen was solved at 2.15 A resolution using the MAD phasing technique, and refined to an R-factor of 0.209. The refined atomic model, which reveals an immunoglobulin-like tertiary fold, differs in important ways from the previously described NMR structure, because the two beta-sheets are significantly further apart and create an internal cavity, which is occupied by a hydrophobic ligand. This interaction is structurally reminiscent of the binding of a prenyl group by a regulatory protein, the Rho guanine nucleotide exchange inhibitor. The crystal structure suggests that binding of non-polar molecules may be essential to the physiological function of the Der p 2 protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 12054778 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12054778}}
==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
[[Category: X-ray structure]]
[[Category: X-ray structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:09:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:58:12 2008''

Revision as of 07:58, 2 July 2008

Image:1ktj.png

Template:STRUCTURE 1ktj

X-ray Structure Of Der P 2, The Major House Dust Mite Allergen

Template:ABSTRACT PUBMED 12054778

About this Structure

1KTJ is a Single protein structure of sequence from Dermatophagoides pteronyssinus. Full crystallographic information is available from OCA.

Reference

The crystal structure of a major dust mite allergen Der p 2, and its biological implications., Derewenda U, Li J, Derewenda Z, Dauter Z, Mueller GA, Rule GS, Benjamin DC, J Mol Biol. 2002 Apr 19;318(1):189-97. PMID:12054778

Page seeded by OCA on Wed Jul 2 10:58:12 2008

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