1ktm

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[[Image:1ktm.gif|left|200px]]
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{{STRUCTURE_1ktm| PDB=1ktm | SCENE= }}
{{STRUCTURE_1ktm| PDB=1ktm | SCENE= }}
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'''SOLUTION STRUCTURE OF FAT DOMAIN OF FOCAL ADHESION KINASE'''
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===SOLUTION STRUCTURE OF FAT DOMAIN OF FOCAL ADHESION KINASE===
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==Overview==
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Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase whose focal adhesion targeting (FAT) domain interacts with other focal adhesion molecules in integrin-mediated signaling. Localization of activated FAK to focal adhesions is indispensable for its function. Here we describe a solution structure of the FAT domain bound to a peptide derived from paxillin, a FAK-binding partner. The FAT domain is composed of four helices that form a "right-turn" elongated bundle; the globular fold is mainly maintained by hydrophobic interactions. The bound peptide further stabilizes the structure. Certain signaling events such as phosphorylation and molecule interplay may induce opening of the helix bundle. Such conformational change is proposed to precede departure of FAK from focal adhesions, which starts focal adhesion turnover.
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(as it appears on PubMed at http://www.pubmed.gov), where 11909967 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11909967}}
==About this Structure==
==About this Structure==
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1KTM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTM OCA].
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1KTM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTM OCA].
==Reference==
==Reference==
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[[Category: Helix bundle]]
[[Category: Helix bundle]]
[[Category: Nmr]]
[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:09:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:58:31 2008''

Revision as of 07:58, 2 July 2008

Image:1ktm.png

Template:STRUCTURE 1ktm

SOLUTION STRUCTURE OF FAT DOMAIN OF FOCAL ADHESION KINASE

Template:ABSTRACT PUBMED 11909967

About this Structure

1KTM is a Single protein structure of sequence from Gallus gallus. Full experimental information is available from OCA.

Reference

Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase., Liu G, Guibao CD, Zheng J, Mol Cell Biol. 2002 Apr;22(8):2751-60. PMID:11909967

Page seeded by OCA on Wed Jul 2 10:58:31 2008

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