1ktz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ktz.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ktz.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ktz| PDB=1ktz | SCENE= }}
{{STRUCTURE_1ktz| PDB=1ktz | SCENE= }}
-
'''Crystal Structure of the Human TGF-beta Type II Receptor Extracellular Domain in Complex with TGF-beta3'''
+
===Crystal Structure of the Human TGF-beta Type II Receptor Extracellular Domain in Complex with TGF-beta3===
-
==Overview==
+
<!--
-
Transforming growth factor-beta (TGF-beta) is the prototype of a large family of structurally related cytokines that play key roles in maintaining cellular homeostasis by signaling through two classes of functionally distinct Ser/Thr kinase receptors, designated as type I and type II. TGF-beta initiates receptor assembly by binding with high affinity to the type II receptor. Here, we present the 2.15 A crystal structure of the extracellular ligand-binding domain of the human TGF-beta type II receptor (ecTbetaR2) in complex with human TGF-beta3. ecTbetaR2 interacts with homodimeric TGF-beta3 by binding identical finger segments at opposite ends of the growth factor. Relative to the canonical 'closed' conformation previously observed in ligand structures across the superfamily, ecTbetaR2-bound TGF-beta3 shows an altered arrangement of its monomeric subunits, designated the 'open' conformation. The mode of TGF-beta3 binding shown by ecTbetaR2 is compatible with both ligand conformations. This, in addition to the predicted mode for TGF-beta binding to the type I receptor ectodomain (ecTbetaR1), suggests an assembly mechanism in which ecTbetaR1 and ecTbetaR2 bind at adjacent positions on the ligand surface and directly contact each other via protein--protein interactions.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11850637}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11850637 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11850637}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Taylor, A B.]]
[[Category: Taylor, A B.]]
[[Category: Cytokine-receptor complex]]
[[Category: Cytokine-receptor complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:10:10 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:59:59 2008''

Revision as of 08:00, 2 July 2008

Image:1ktz.png

Template:STRUCTURE 1ktz

Crystal Structure of the Human TGF-beta Type II Receptor Extracellular Domain in Complex with TGF-beta3

Template:ABSTRACT PUBMED 11850637

About this Structure

1KTZ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex., Hart PJ, Deep S, Taylor AB, Shu Z, Hinck CS, Hinck AP, Nat Struct Biol. 2002 Mar;9(3):203-8. PMID:11850637

Page seeded by OCA on Wed Jul 2 10:59:59 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ktz"
Personal tools