1kuj

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[[Image:1kuj.gif|left|200px]]
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{{Seed}}
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[[Image:1kuj.png|left|200px]]
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{{STRUCTURE_1kuj| PDB=1kuj | SCENE= }}
{{STRUCTURE_1kuj| PDB=1kuj | SCENE= }}
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'''Crystal structure of Jacalin complexed with 1-O-methyl-alpha-D-mannose'''
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===Crystal structure of Jacalin complexed with 1-O-methyl-alpha-D-mannose===
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==Overview==
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Evidence is presented that the specificity of jacalin, the seed lectin from jack fruit (Artocarpus integrifolia), is not directed exclusively against the T-antigen disaccharide Galbeta1,3GalNAc, lactose and galactose, but also against mannose and oligomannosides. Biochemical analyses based on surface-plasmon-resonance measurements, combined with the X-ray-crystallographic determination of the structure of a jacalin-alpha-methyl-mannose complex at 2 A resolution, demonstrated clearly that jacalin is fully capable of binding mannose. Besides mannose, jacalin also interacts readily with glucose, N-acetylneuraminic acid and N-acetylmuramic acid. Structural analyses demonstrated that the relatively large size of the carbohydrate-binding site enables jacalin to accommodate monosaccharides with different hydroxyl conformations and provided unambiguous evidence that the beta-prism structure of jacalin is a sufficiently flexible structural scaffold to confer different carbohydrate-binding specificities to a single lectin.
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The line below this paragraph, {{ABSTRACT_PUBMED_11988090}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11988090 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11988090}}
==About this Structure==
==About this Structure==
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[[Category: Carbohydrate binding]]
[[Category: Carbohydrate binding]]
[[Category: Lectin]]
[[Category: Lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:11:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:01:49 2008''

Revision as of 08:01, 2 July 2008

Image:1kuj.png

Template:STRUCTURE 1kuj

Crystal structure of Jacalin complexed with 1-O-methyl-alpha-D-mannose

Template:ABSTRACT PUBMED 11988090

About this Structure

1KUJ is a Protein complex structure of sequences from Artocarpus integer. Full crystallographic information is available from OCA.

Reference

Structural basis for the unusual carbohydrate-binding specificity of jacalin towards galactose and mannose., Bourne Y, Astoul CH, Zamboni V, Peumans WJ, Menu-Bouaouiche L, Van Damme EJ, Barre A, Rouge P, Biochem J. 2002 May 15;364(Pt 1):173-80. PMID:11988090

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