1kwa

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{{STRUCTURE_1kwa| PDB=1kwa | SCENE= }}
{{STRUCTURE_1kwa| PDB=1kwa | SCENE= }}
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'''HUMAN CASK/LIN-2 PDZ DOMAIN'''
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===HUMAN CASK/LIN-2 PDZ DOMAIN===
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==Overview==
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PDZ domain containing proteins assist formation of cell-cell junctions and localization of membrane protein receptors and ion channels. PDZ domains interact with the C-terminal residues of a particular target membrane protein. Based on their binding specificities and sequence homologies, PDZ domains fall into two classes. The first crystal structure of a class II PDZ domain, that of hCASK, has been solved by multi-wavelength anomalous dispersion phasing. Complex formation with the C-terminus of a neighboring non-crystallographically related PDZ domain reveals interactions between hCASK and its ligand. Class II PDZ domains differ from class I domains by formation of a second hydrophobic binding pocket. The C-terminal carboxylate binding loop of the PDZ domain is structurally conserved in both classes suggesting a generalized carboxylate binding motif (h-Gly-h) where h is a hydrophobic residue.
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{{ABSTRACT_PUBMED_9546224}}
==About this Structure==
==About this Structure==
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[[Category: Receptor clustering]]
[[Category: Receptor clustering]]
[[Category: Syndecan]]
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Revision as of 08:08, 2 July 2008

Image:1kwa.png

Template:STRUCTURE 1kwa

HUMAN CASK/LIN-2 PDZ DOMAIN

Template:ABSTRACT PUBMED 9546224

About this Structure

1KWA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition., Daniels DL, Cohen AR, Anderson JM, Brunger AT, Nat Struct Biol. 1998 Apr;5(4):317-25. PMID:9546224

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