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1kxl

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[[Image:1kxl.gif|left|200px]]
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{{STRUCTURE_1kxl| PDB=1kxl | SCENE= }}
{{STRUCTURE_1kxl| PDB=1kxl | SCENE= }}
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'''Solution Structure of the Cdc13 DNA-binding Domain in a Complex with Single-Stranded Telomeric DNA (DNA structure not modeled)'''
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===Solution Structure of the Cdc13 DNA-binding Domain in a Complex with Single-Stranded Telomeric DNA (DNA structure not modeled)===
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==Overview==
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The essential Cdc13 protein in the yeast Saccharomyces cerevisiae is a single-stranded telomeric DNA binding protein required for chromosome end protection and telomere replication. Here we report the solution structure of the Cdc13 DNA binding domain in complex with telomeric DNA. The structure reveals the use of a single OB (oligonucleotide/oligosaccharide binding) fold augmented by an unusually large loop for DNA recognition. This OB fold is structurally similar to OB folds found in the ciliated protozoan telomere end-binding protein, although no sequence similarity is apparent between them. The common usage of an OB fold for telomeric DNA interaction demonstrates conservation of end-protection mechanisms among eukaryotes.
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(as it appears on PubMed at http://www.pubmed.gov), where 11935027 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11935027}}
==About this Structure==
==About this Structure==
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1KXL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXL OCA].
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1KXL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXL OCA].
==Reference==
==Reference==
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[[Category: Single-stranded dna]]
[[Category: Single-stranded dna]]
[[Category: Telomere]]
[[Category: Telomere]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:17:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:14:17 2008''

Revision as of 08:14, 2 July 2008

Image:1kxl.png

Template:STRUCTURE 1kxl

Solution Structure of the Cdc13 DNA-binding Domain in a Complex with Single-Stranded Telomeric DNA (DNA structure not modeled)

Template:ABSTRACT PUBMED 11935027

About this Structure

1KXL is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Conserved structure for single-stranded telomeric DNA recognition., Mitton-Fry RM, Anderson EM, Hughes TR, Lundblad V, Wuttke DS, Science. 2002 Apr 5;296(5565):145-7. PMID:11935027

Page seeded by OCA on Wed Jul 2 11:14:17 2008

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