1kxr

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[[Image:1kxr.gif|left|200px]]
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{{STRUCTURE_1kxr| PDB=1kxr | SCENE= }}
{{STRUCTURE_1kxr| PDB=1kxr | SCENE= }}
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'''Crystal Structure of Calcium-Bound Protease Core of Calpain I'''
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===Crystal Structure of Calcium-Bound Protease Core of Calpain I===
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==Overview==
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Ca(2+) signaling by calpains leads to controlled proteolysis during processes ranging from cytoskeleton remodeling in mammals to sex determination in nematodes. Deregulated Ca(2+) levels result in aberrant proteolysis by calpains, which contributes to tissue damage in heart and brain ischemias as well as neurodegeneration in Alzheimer's disease. Here we show that activation of the protease core of mu calpain requires cooperative binding of two Ca(2+) atoms at two non-EF-hand sites revealed in the 2.1 A crystal structure. Conservation of the Ca(2+) binding residues defines an ancestral general mechanism of activation for most calpain isoforms, including some that lack EF-hand domains. The protease region is not affected by the endogenous inhibitor, calpastatin, and may contribute to calpain-mediated pathologies when the core is released by autoproteolysis.
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The line below this paragraph, {{ABSTRACT_PUBMED_11893336}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11893336 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11893336}}
==About this Structure==
==About this Structure==
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[[Category: Papain-related]]
[[Category: Papain-related]]
[[Category: Two novel cooperative calcium site]]
[[Category: Two novel cooperative calcium site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:18:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:14:59 2008''

Revision as of 08:15, 2 July 2008

Image:1kxr.png

Template:STRUCTURE 1kxr

Crystal Structure of Calcium-Bound Protease Core of Calpain I

Template:ABSTRACT PUBMED 11893336

About this Structure

1KXR is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

A Ca(2+) switch aligns the active site of calpain., Moldoveanu T, Hosfield CM, Lim D, Elce JS, Jia Z, Davies PL, Cell. 2002 Mar 8;108(5):649-60. PMID:11893336

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