1kyh

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{{STRUCTURE_1kyh| PDB=1kyh | SCENE= }}
{{STRUCTURE_1kyh| PDB=1kyh | SCENE= }}
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'''Structure of Bacillus subtilis YxkO, a Member of the UPF0031 Family and a Putative Kinase'''
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===Structure of Bacillus subtilis YxkO, a Member of the UPF0031 Family and a Putative Kinase===
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==Overview==
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We determined the 1.6-A resolution crystal structure of a conserved hypothetical 29.9-kDa protein from the SIGY-CYDD intergenic region encoded by a Bacillus subtilis open reading frame in the YXKO locus. YXKO homologues are broadly distributed and are by and large described as proteins with unknown function. The YXKO protein has an alpha/beta fold and shows high structural homology to the members of a ribokinase-like superfamily. However, YXKO is the only member of this superfamily known to form tetramers. Putative binding sites for adenosine triphosphate (ATP), a substrate, and Mg(2+)-binding sites were revealed in the structure of the protein, based on high structural similarity to ATP-dependent members of the superfamily. Two adjacent monomers contribute residues to the active site. The crystal structure provides valuable information about the YXKO protein's tertiary and quaternary structure, the biochemical function of YXKO and its homologues, and the evolution of its ribokinase-like superfamily.
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{{ABSTRACT_PUBMED_12457846}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Unknown function]]
[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:18:00 2008''

Revision as of 08:18, 2 July 2008

Image:1kyh.png

Template:STRUCTURE 1kyh

Structure of Bacillus subtilis YxkO, a Member of the UPF0031 Family and a Putative Kinase

Template:ABSTRACT PUBMED 12457846

About this Structure

1KYH is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Structure of Bacillus subtilis YXKO--a member of the UPF0031 family and a putative kinase., Zhang RG, Grembecka J, Vinokour E, Collart F, Dementieva I, Minor W, Joachimiak A, J Struct Biol. 2002 Sep;139(3):161-70. PMID:12457846

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