1kzf

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{{STRUCTURE_1kzf| PDB=1kzf | SCENE= }}
{{STRUCTURE_1kzf| PDB=1kzf | SCENE= }}
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'''Crystal Structure of the Acyl-homoserine Lactone Synthase, EsaI'''
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===Crystal Structure of the Acyl-homoserine Lactone Synthase, EsaI===
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==Overview==
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Synthesis and detection of acyl-homoserine lactones (AHLs) enables many gram-negative bacteria to engage in quorum sensing, an intercellular signaling mechanism that activates differentiation to virulent and biofilm lifestyles. The AHL synthases catalyze acylation of S-adenosyl-L-methionine by acyl-acyl carrier protein and lactonization of the methionine moiety to give AHLs. The crystal structure of the AHL synthase, EsaI, determined at 1.8 A resolution, reveals a remarkable structural similarity to the N-acetyltransferases and defines a common phosphopantetheine binding fold as the catalytic core. Critical residues responsible for catalysis and acyl chain specificity have been identified from a modeled substrate complex and verified through functional analysis in vivo. A mechanism for the N-acylation of S-adenosyl-L-methionine by 3-oxo-hexanoyl-acyl carrier protein is proposed.
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(as it appears on PubMed at http://www.pubmed.gov), where 11931774 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11931774}}
==About this Structure==
==About this Structure==
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[[Category: Bacterial pathogenesis]]
[[Category: Bacterial pathogenesis]]
[[Category: Quorum sensing]]
[[Category: Quorum sensing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:21:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:21:30 2008''

Revision as of 08:21, 2 July 2008

Image:1kzf.png

Template:STRUCTURE 1kzf

Crystal Structure of the Acyl-homoserine Lactone Synthase, EsaI

Template:ABSTRACT PUBMED 11931774

About this Structure

1KZF is a Single protein structure of sequence from Pantoea stewartii subsp. stewartii. Full crystallographic information is available from OCA.

Reference

Structural basis and specificity of acyl-homoserine lactone signal production in bacterial quorum sensing., Watson WT, Minogue TD, Val DL, von Bodman SB, Churchill ME, Mol Cell. 2002 Mar;9(3):685-94. PMID:11931774

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