1kzs

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{{STRUCTURE_1kzs| PDB=1kzs | SCENE= }}
{{STRUCTURE_1kzs| PDB=1kzs | SCENE= }}
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'''Structure of Human Immunodeficiency Virus Type 1 Vpr(34-51) Peptide in Aqueous TFE Solution'''
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===Structure of Human Immunodeficiency Virus Type 1 Vpr(34-51) Peptide in Aqueous TFE Solution===
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==Overview==
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Human immunodeficiency virus type 1 protein R (HIV-1 Vpr) promotes nuclear entry of viral nucleic acids in nondividing cells, causes G(2) cell cycle arrest and is involved in cellular differentiation and cell death. Vpr subcellular localization is as variable as its functions. It is known, that consistent with its role in nuclear transport, Vpr localizes to the nuclear envelope of human cells. Further, a reported ion channel activity of Vpr is clearly dependent on its localization in or at membranes. We focused our structural studies on the secondary structure of a peptide consisting of residues 34-51 of HIV-1 Vpr. This part of Vpr plays an important role in Vpr oligomerization, contributes to cell cycle arrest activity, and is essential for virion incorporation and binding to HHR23A, a protein involved in DNA repair. Employing NMR spectroscopy we found this part of Vpr to be almost completely alpha helical in the presence of micelles, as well as in trifluoroethanol containing and methanol/chloroform solvent. Our results provide structural data suggesting residues 34-51 of Vpr to contain an amphipathic, leucine-zipper-like alpha helix, which serves as a basis for oligomerization of Vpr and its interactions with cellular and viral factors involved in subcellular localization and virion incorporation of Vpr.
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(as it appears on PubMed at http://www.pubmed.gov), where 12084067 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12084067}}
==About this Structure==
==About this Structure==
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1KZS is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZS OCA].
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1KZS is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZS OCA].
==Reference==
==Reference==
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[[Category: Tfe]]
[[Category: Tfe]]
[[Category: Vpr]]
[[Category: Vpr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:22:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:23:00 2008''

Revision as of 08:23, 2 July 2008

Image:1kzs.png

Template:STRUCTURE 1kzs

Structure of Human Immunodeficiency Virus Type 1 Vpr(34-51) Peptide in Aqueous TFE Solution

Template:ABSTRACT PUBMED 12084067

About this Structure

1KZS is a Single protein structure. Full experimental information is available from OCA.

Reference

Structure of human immunodeficiency virus type 1 Vpr(34-51) peptide in micelle containing aqueous solution., Engler A, Stangler T, Willbold D, Eur J Biochem. 2002 Jul;269(13):3264-9. PMID:12084067

Page seeded by OCA on Wed Jul 2 11:23:00 2008

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