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1l0n

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[[Image:1l0n.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1l0n| PDB=1l0n | SCENE= }}
{{STRUCTURE_1l0n| PDB=1l0n | SCENE= }}
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'''native structure of bovine mitochondrial cytochrome bc1 complex'''
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===native structure of bovine mitochondrial cytochrome bc1 complex===
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==Overview==
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Ubiquinol cytochrome c oxido-reductase (EC. 1.10.2.2, bc1) is an integral membrane protein complex essential to cellular respiration. Structures of the 11-subunit mitochondrial bc1 complex were determined with and without the fungicide famoxadone. Specific inhibition by famoxadone is achieved through a coordinated optimization of aromatic-aromatic interactions where conformational rearrangements in famoxadone and in residues lining the inhibitor-binding pocket produce a network of aromatic-aromatic interactions that mimic the crystal lattice of benzene. The profound aromatic-aromatic interactions as supported by prior mutagenesis provide a structural basis for specific protein-ligand interaction in a hydrophobic environment. Dramatic conformational changes, both in cyt. b and ISP subunits in the inhibitor-protein complex, confer experimental evidence for a functional role of cytochrome b in the induced conformational arrest of ISP and allow the identification of a possible intrasubunit signal transduction pathway that controls the movement of ISP. These results support an inhibitory mechanism that is consistent with the requirement for ISP movement in the electron transfer of this complex.
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The line below this paragraph, {{ABSTRACT_PUBMED_12269811}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12269811 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12269811}}
==About this Structure==
==About this Structure==
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[[Category: Mitochondrial processing protease]]
[[Category: Mitochondrial processing protease]]
[[Category: Mpp]]
[[Category: Mpp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:24:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:26:38 2008''

Revision as of 08:26, 2 July 2008

Image:1l0n.png

Template:STRUCTURE 1l0n

native structure of bovine mitochondrial cytochrome bc1 complex

Template:ABSTRACT PUBMED 12269811

About this Structure

1L0N is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition., Gao X, Wen X, Yu C, Esser L, Tsao S, Quinn B, Zhang L, Yu L, Xia D, Biochemistry. 2002 Oct 1;41(39):11692-702. PMID:12269811

Page seeded by OCA on Wed Jul 2 11:26:38 2008

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