1l1d

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{{STRUCTURE_1l1d| PDB=1l1d | SCENE= }}
{{STRUCTURE_1l1d| PDB=1l1d | SCENE= }}
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'''Crystal structure of the C-terminal methionine sulfoxide reductase domain (MsrB) of N. gonorrhoeae pilB'''
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===Crystal structure of the C-terminal methionine sulfoxide reductase domain (MsrB) of N. gonorrhoeae pilB===
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==Overview==
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Methionine sulfoxide reductases (Msr) protect against oxidative damage that can contribute to cell death. The tandem Msr domains (MsrA and MsrB) of the pilB protein from Neisseria gonorrhoeae each reduce different epimeric forms of methionine sulfoxide. The overall fold of the MsrB domain revealed by the 1.85 A crystal structure shows no resemblance to the previously determined MsrA structures from other organisms. Despite the lack of homology, the active sites show approximate mirror symmetry. In each case, conserved amino acid motifs mediate the stereo-specific recognition and reduction of the substrate. Unlike the MsrA domain, the MsrB domain activates the cysteine or selenocysteine nucleophile through a unique Cys-Arg-Asp/Glu catalytic triad. The collapse of the reaction intermediate most likely results in the formation of a sulfenic or selenenic acid moiety. Regeneration of the active site occurs through a series of thiol-disulfide exchange steps involving another active site Cys residue and thioredoxin. These observations have broad implications for modular catalysis, antibiotic drug design and continuing longevity studies in mammals.
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(as it appears on PubMed at http://www.pubmed.gov), where 11938352 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11938352}}
==About this Structure==
==About this Structure==
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[[Category: Msrb]]
[[Category: Msrb]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:25:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:28:46 2008''

Revision as of 08:28, 2 July 2008

Image:1l1d.png

Template:STRUCTURE 1l1d

Crystal structure of the C-terminal methionine sulfoxide reductase domain (MsrB) of N. gonorrhoeae pilB

Template:ABSTRACT PUBMED 11938352

About this Structure

1L1D is a Single protein structure of sequence from Neisseria gonorrhoeae. Full crystallographic information is available from OCA.

Reference

The mirrored methionine sulfoxide reductases of Neisseria gonorrhoeae pilB., Lowther WT, Weissbach H, Etienne F, Brot N, Matthews BW, Nat Struct Biol. 2002 May;9(5):348-52. PMID:11938352

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