1l2w

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[[Image:1l2w.gif|left|200px]]
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{{STRUCTURE_1l2w| PDB=1l2w | SCENE= }}
{{STRUCTURE_1l2w| PDB=1l2w | SCENE= }}
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'''Crystal Structure of the Yersinia Virulence Effector YopE Chaperone-binding Domain in Complex with its Secretion Chaperone, SycE'''
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===Crystal Structure of the Yersinia Virulence Effector YopE Chaperone-binding Domain in Complex with its Secretion Chaperone, SycE===
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==Overview==
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The type III secretion system (TTSS) of Gram-negative bacterial pathogens delivers effector proteins required for virulence directly into the cytosol of host cells. Delivery of many effectors depends on association with specific cognate chaperones in the bacterial cytosol. The mechanism of chaperone action is not understood. Here we present biochemical and crystallographic results on the Yersinia SycE-YopE chaperone-effector complex that contradict previous models of chaperone function and demonstrate that chaperone action is isolated to only a small portion of the effector. This, together with evidence for stereochemical conservation between chaperone-effector complexes, which are otherwise unrelated in sequence, indicates that these complexes function as general, three-dimensional TTSS secretion signals and may endow a temporal order to secretion.
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(as it appears on PubMed at http://www.pubmed.gov), where 12049734 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12049734}}
==About this Structure==
==About this Structure==
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[[Category: Phillips, R M.]]
[[Category: Phillips, R M.]]
[[Category: Chaperone and virulence protein]]
[[Category: Chaperone and virulence protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:28:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:34:47 2008''

Revision as of 08:34, 2 July 2008

Image:1l2w.png

Template:STRUCTURE 1l2w

Crystal Structure of the Yersinia Virulence Effector YopE Chaperone-binding Domain in Complex with its Secretion Chaperone, SycE

Template:ABSTRACT PUBMED 12049734

About this Structure

1L2W is a Single protein structure of sequence from Yersinia pseudotuberculosis. Full crystallographic information is available from OCA.

Reference

Three-dimensional secretion signals in chaperone-effector complexes of bacterial pathogens., Birtalan SC, Phillips RM, Ghosh P, Mol Cell. 2002 May;9(5):971-80. PMID:12049734

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