1l2x

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{{Seed}}
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{{STRUCTURE_1l2x| PDB=1l2x | SCENE= }}
{{STRUCTURE_1l2x| PDB=1l2x | SCENE= }}
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'''Atomic Resolution Crystal Structure of a Viral RNA Pseudoknot'''
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===Atomic Resolution Crystal Structure of a Viral RNA Pseudoknot===
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==Overview==
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Many pathogenic viruses use programmed -1 ribosomal frameshifting to regulate translation of their structural and enzymatic proteins from polycistronic mRNAs. Frameshifting is commonly stimulated by a pseudoknot located downstream from a slippery sequence, the latter positioned at the ribosomal A and P sites. We report here the structures of two crystal forms of the frameshifting RNA pseudoknot from beet western yellow virus at resolutions of 1.25 and 2.85 A. Because of the very high resolution of 1.25 A, ten mono- and divalent metal ions per asymmetric unit could be identified, giving insight into potential roles of metal ions in stabilizing the pseudoknot. A magnesium ion located at the junction of the two pseudoknot stems appears to play a crucial role in stabilizing the structure. Because the two crystal forms exhibit mostly unrelated packing interactions and local crystallographic disorder in the high-resolution form was resolvable, the two structures offer the most detailed view yet of the conformational preference and flexibility of an RNA pseudoknot.
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(as it appears on PubMed at http://www.pubmed.gov), where 11904368 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11904368}}
==About this Structure==
==About this Structure==
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[[Category: Pseudoknot]]
[[Category: Pseudoknot]]
[[Category: Viral rna]]
[[Category: Viral rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:28:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:34:54 2008''

Revision as of 08:34, 2 July 2008

Image:1l2x.png

Template:STRUCTURE 1l2x

Atomic Resolution Crystal Structure of a Viral RNA Pseudoknot

Template:ABSTRACT PUBMED 11904368

About this Structure

Full crystallographic information is available from OCA.

Reference

Metal ions and flexibility in a viral RNA pseudoknot at atomic resolution., Egli M, Minasov G, Su L, Rich A, Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4302-7. Epub 2002 Mar 19. PMID:11904368

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