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1l4a

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[[Image:1l4a.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1l4a| PDB=1l4a | SCENE= }}
{{STRUCTURE_1l4a| PDB=1l4a | SCENE= }}
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'''X-RAY STRUCTURE OF THE NEURONAL COMPLEXIN/SNARE COMPLEX FROM THE SQUID LOLIGO PEALEI'''
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===X-RAY STRUCTURE OF THE NEURONAL COMPLEXIN/SNARE COMPLEX FROM THE SQUID LOLIGO PEALEI===
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==Overview==
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Nerve terminals release neurotransmitters from vesicles into the synaptic cleft upon transient increases in intracellular Ca(2+). This exocytotic process requires the formation of trans SNARE complexes and is regulated by accessory proteins including the complexins. Here we report the crystal structure of a squid core complexin-SNARE complex at 2.95-A resolution. A helical segment of complexin binds in anti-parallel fashion to the four-helix bundle of the core SNARE complex and interacts at its C terminus with syntaxin and synaptobrevin around the ionic zero layer of the SNARE complex. We propose that this structure is part of a multiprotein fusion machinery that regulates vesicle fusion at a late pre-fusion stage. Accordingly, Ca(2+) may initiate membrane fusion by acting directly or indirectly on complexin, thus allowing the conformational transitions of the trans SNARE complex that are thought to drive membrane fusion.
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The line below this paragraph, {{ABSTRACT_PUBMED_12004067}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12004067 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12004067}}
==About this Structure==
==About this Structure==
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[[Category: Snare]]
[[Category: Snare]]
[[Category: Snare complex]]
[[Category: Snare complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:31:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:40:48 2008''

Revision as of 08:40, 2 July 2008

Image:1l4a.png

Template:STRUCTURE 1l4a

X-RAY STRUCTURE OF THE NEURONAL COMPLEXIN/SNARE COMPLEX FROM THE SQUID LOLIGO PEALEI

Template:ABSTRACT PUBMED 12004067

About this Structure

1L4A is a Protein complex structure of sequences from Loligo pealei. Full crystallographic information is available from OCA.

Reference

X-ray structure of a neuronal complexin-SNARE complex from squid., Bracher A, Kadlec J, Betz H, Weissenhorn W, J Biol Chem. 2002 Jul 19;277(29):26517-23. Epub 2002 May 9. PMID:12004067

Page seeded by OCA on Wed Jul 2 11:40:48 2008

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