1l5i

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{{STRUCTURE_1l5i| PDB=1l5i | SCENE= }}
{{STRUCTURE_1l5i| PDB=1l5i | SCENE= }}
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'''30-CONFORMER NMR ENSEMBLE OF THE N-TERMINAL, DNA-BINDING DOMAIN OF THE REPLICATION INITIATION PROTEIN FROM A GEMINIVIRUS (TOMATO YELLOW LEAF CURL VIRUS-SARDINIA)'''
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===30-CONFORMER NMR ENSEMBLE OF THE N-TERMINAL, DNA-BINDING DOMAIN OF THE REPLICATION INITIATION PROTEIN FROM A GEMINIVIRUS (TOMATO YELLOW LEAF CURL VIRUS-SARDINIA)===
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==Overview==
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Rolling circle replication is a mechanism for copying single-stranded genomes by means of double-stranded intermediates. A multifunctional replication initiator protein (Rep) is indispensable for the precise initiation and termination of this process. Despite the ubiquitous presence and fundamental importance of rolling circle replication elements, structural information on their respective replication initiators is still missing. Here we present the solution NMR structure of the catalytic domain of Rep, the initiator protein of tomato yellow leaf curl virus. It is composed of a central five-stranded anti-parallel beta-sheet, flanked by a small two-stranded beta-sheet, a beta-hairpin and two alpha-helices. Surprisingly, the structure reveals that the catalytic Rep domain is related to a large group of proteins that bind RNA or DNA. Identification of Rep as resembling the family of ribonucleoprotein/RNA-recognition motif fold proteins establishes a structure-based evolutionary link between RNA binding proteins, splicing factors, and replication initiators of prokaryotic and eukaryotic single-stranded DNA elements and mammalian DNA tumor viruses.
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{{ABSTRACT_PUBMED_12130667}}
==About this Structure==
==About this Structure==
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1L5I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Tomato_yellow_leaf_curl_sardinia_virus Tomato yellow leaf curl sardinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L5I OCA].
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1L5I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Tomato_yellow_leaf_curl_sardinia_virus Tomato yellow leaf curl sardinia virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L5I OCA].
==Reference==
==Reference==
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[[Category: A+b fold]]
[[Category: A+b fold]]
[[Category: Rbd-like fold]]
[[Category: Rbd-like fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:44:39 2008''

Revision as of 08:44, 2 July 2008

Image:1l5i.png

Template:STRUCTURE 1l5i

30-CONFORMER NMR ENSEMBLE OF THE N-TERMINAL, DNA-BINDING DOMAIN OF THE REPLICATION INITIATION PROTEIN FROM A GEMINIVIRUS (TOMATO YELLOW LEAF CURL VIRUS-SARDINIA)

Template:ABSTRACT PUBMED 12130667

About this Structure

1L5I is a Single protein structure of sequence from Tomato yellow leaf curl sardinia virus. Full experimental information is available from OCA.

Reference

The structure of a replication initiator unites diverse aspects of nucleic acid metabolism., Campos-Olivas R, Louis JM, Clerot D, Gronenborn B, Gronenborn AM, Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10310-5. Epub 2002 Jul 18. PMID:12130667

Page seeded by OCA on Wed Jul 2 11:44:39 2008

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