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1l5j

From Proteopedia

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[[Image:1l5j.gif|left|200px]]
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{{Seed}}
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[[Image:1l5j.png|left|200px]]
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{{STRUCTURE_1l5j| PDB=1l5j | SCENE= }}
{{STRUCTURE_1l5j| PDB=1l5j | SCENE= }}
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'''CRYSTAL STRUCTURE OF E. COLI ACONITASE B.'''
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===CRYSTAL STRUCTURE OF E. COLI ACONITASE B.===
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==Overview==
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The major bifunctional aconitase of Escherichia coli (AcnB) serves as either an enzymic catalyst or a mRNA-binding post-transcriptional regulator, depending on the status of its iron sulfur cluster. AcnB represents a large, distinct group of Gram-negative bacterial aconitases that have an altered domain organization relative to mitochondrial aconitase and other aconitases. Here the 2.4 A structure of E. coli AcnB reveals a high degree of conservation at the active site despite its domain reorganization. It also reveals that the additional domain, characteristic of the AcnB subfamily, is a HEAT-like domain, implying a role in protein protein recognition. This domain packs against the remainder of the protein to form a tunnel leading to the aconitase active site, potentially for substrate channeling.
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The line below this paragraph, {{ABSTRACT_PUBMED_11992126}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11992126 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11992126}}
==About this Structure==
==About this Structure==
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[[Category: Molecular recognition]]
[[Category: Molecular recognition]]
[[Category: Rna binding]]
[[Category: Rna binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:33:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:44:59 2008''

Revision as of 08:45, 2 July 2008

Image:1l5j.png

Template:STRUCTURE 1l5j

CRYSTAL STRUCTURE OF E. COLI ACONITASE B.

Template:ABSTRACT PUBMED 11992126

About this Structure

1L5J is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

E. coli aconitase B structure reveals a HEAT-like domain with implications for protein-protein recognition., Williams CH, Stillman TJ, Barynin VV, Sedelnikova SE, Tang Y, Green J, Guest JR, Artymiuk PJ, Nat Struct Biol. 2002 Jun;9(6):447-52. PMID:11992126

Page seeded by OCA on Wed Jul 2 11:44:59 2008

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