1l6n

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{{STRUCTURE_1l6n| PDB=1l6n | SCENE= }}
{{STRUCTURE_1l6n| PDB=1l6n | SCENE= }}
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'''STRUCTURE OF THE N-TERMINAL 283-RESIDUE FRAGMENT OF THE HIV-1 GAG POLYPROTEIN'''
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===STRUCTURE OF THE N-TERMINAL 283-RESIDUE FRAGMENT OF THE HIV-1 GAG POLYPROTEIN===
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==Overview==
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The capsid protein (CA) of the mature human immunodeficiency virus (HIV) contains an N-terminal beta-hairpin that is essential for formation of the capsid core particle. CA is generated by proteolytic cleavage of the Gag precursor polyprotein during viral maturation. We have determined the NMR structure of a 283-residue N-terminal fragment of immature HIV-1 Gag (Gag(283)), which includes the intact matrix (MA) and N-terminal capsid (CA(N)) domains. The beta-hairpin is unfolded in Gag(283), consistent with the proposal that hairpin formation occurs subsequent to proteolytic cleavage of Gag, triggering capsid assembly. Comparison of the immature and mature CA(N) structures reveals that beta-hairpin formation induces a approximately 2 A displacement of helix 6 and a concomitant displacement of the cyclophylin-A (CypA)-binding loop, suggesting a possible allosteric mechanism for CypA-mediated destabilization of the capsid particle during infectivity.
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The line below this paragraph, {{ABSTRACT_PUBMED_12032547}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12032547 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12032547}}
==About this Structure==
==About this Structure==
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1L6N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6N OCA].
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1L6N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6N OCA].
==Reference==
==Reference==
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[[Category: Matrix]]
[[Category: Matrix]]
[[Category: Maturation]]
[[Category: Maturation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:35:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:48:46 2008''

Revision as of 08:48, 2 July 2008

Image:1l6n.png

Template:STRUCTURE 1l6n

STRUCTURE OF THE N-TERMINAL 283-RESIDUE FRAGMENT OF THE HIV-1 GAG POLYPROTEIN

Template:ABSTRACT PUBMED 12032547

About this Structure

1L6N is a Single protein structure of sequence from Human immunodeficiency virus 1. Full experimental information is available from OCA.

Reference

Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyprotein., Tang C, Ndassa Y, Summers MF, Nat Struct Biol. 2002 Jul;9(7):537-43. PMID:12032547

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