1l6o

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[[Image:1l6o.gif|left|200px]]
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{{Seed}}
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[[Image:1l6o.png|left|200px]]
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{{STRUCTURE_1l6o| PDB=1l6o | SCENE= }}
{{STRUCTURE_1l6o| PDB=1l6o | SCENE= }}
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'''XENOPUS DISHEVELLED PDZ DOMAIN'''
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===XENOPUS DISHEVELLED PDZ DOMAIN===
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==Overview==
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Dapper was isolated in a screen for proteins interacting with Dishevelled, a key factor in Wnt signaling. Dapper and Dishevelled colocalize intracellularly and form a complex with Axin, GSK-3, CKI, and beta-catenin. Overexpression of Dapper increases Axin and GSK-3 in this complex, resulting in decreased soluble beta-catenin and decreased activation of beta-catenin-responsive genes. Dapper also inhibits activation by Dishevelled of c-Jun N-terminal kinase (JNK), a component of beta-catenin-independent Frizzled signaling. Inhibition of Dapper activates both beta-catenin-responsive genes and an AP1-responsive promoter, demonstrating that Dapper is a general Dishevelled antagonist. Depletion of maternal Dapper RNA from Xenopus embryos results in loss of notochord and head structures, demonstrating that Dapper is required for normal vertebrate development.
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(as it appears on PubMed at http://www.pubmed.gov), where 11970895 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11970895}}
==About this Structure==
==About this Structure==
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[[Category: Pdz]]
[[Category: Pdz]]
[[Category: Wnt pathway]]
[[Category: Wnt pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:35:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:49:11 2008''

Revision as of 08:49, 2 July 2008

Image:1l6o.png

Template:STRUCTURE 1l6o

XENOPUS DISHEVELLED PDZ DOMAIN

Template:ABSTRACT PUBMED 11970895

About this Structure

1L6O is a Protein complex structure of sequences from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation., Cheyette BN, Waxman JS, Miller JR, Takemaru K, Sheldahl LC, Khlebtsova N, Fox EP, Earnest T, Moon RT, Dev Cell. 2002 Apr;2(4):449-61. PMID:11970895

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