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1l7c

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{{STRUCTURE_1l7c| PDB=1l7c | SCENE= }}
{{STRUCTURE_1l7c| PDB=1l7c | SCENE= }}
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'''alpha-catenin fragment, residues 385-651'''
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===alpha-catenin fragment, residues 385-651===
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==Overview==
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alpha-Catenin is an integral component of adherens junctions, where it links cadherins to the actin cytoskeleton. alpha-Catenin is also required for the colocalization of the nectin/afadin/ponsin adhesion system to adherens junctions, and it specifically associates with the nectin-binding protein afadin. A proteolytic fragment of alpha-catenin, residues 385-651, contains the afadin-binding site. The three-dimensional structure of this fragment comprises two side-by-side four-helix bundles, both of which are required for afadin binding. The alpha-catenin fragment 385-651 binds afadin more strongly than the full-length protein, suggesting that the full-length protein harbors a cryptic binding site for afadin. Comparison of the alpha-catenin 385-651 structure with the recently solved structure of the alpha-catenin M-fragment (Yang, J., Dokurno, P., Tonks, N. K., and Barford, D. (2001) EMBO J. 20, 3645-3656) reveals a surprising flexibility in the orientation of the two four-helix bundles. alpha-Catenin and the actin-binding protein vinculin share sequence and most likely structural similarity within their actin-binding domains. Despite this homology, actin binding requires additional sequences adjacent to this region.
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(as it appears on PubMed at http://www.pubmed.gov), where 11907041 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11907041}}
==About this Structure==
==About this Structure==
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[[Category: Weis, W I.]]
[[Category: Weis, W I.]]
[[Category: Four-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:37:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:51:49 2008''

Revision as of 08:51, 2 July 2008

Image:1l7c.png

Template:STRUCTURE 1l7c

alpha-catenin fragment, residues 385-651

Template:ABSTRACT PUBMED 11907041

About this Structure

1L7C is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin., Pokutta S, Drees F, Takai Y, Nelson WJ, Weis WI, J Biol Chem. 2002 May 24;277(21):18868-74. Epub 2002 Mar 20. PMID:11907041

Page seeded by OCA on Wed Jul 2 11:51:49 2008

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