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1l7z

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{{STRUCTURE_1l7z| PDB=1l7z | SCENE= }}
{{STRUCTURE_1l7z| PDB=1l7z | SCENE= }}
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'''Crystal structure of Ca2+/Calmodulin complexed with myristoylated CAP-23/NAP-22 peptide'''
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===Crystal structure of Ca2+/Calmodulin complexed with myristoylated CAP-23/NAP-22 peptide===
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==Overview==
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A variety of viral and signal transduction proteins are known to be myristoylated. Although the role of myristoylation in protein-lipid interaction is well established, the involvement of myristoylation in protein-protein interactions is less well understood. CAP-23/NAP-22 is a brain-specific protein kinase C substrate protein that is involved in axon regeneration. Although the protein lacks any canonical calmodulin (CaM)-binding domain, it binds CaM with high affinity. The binding of CAP-23/NAP-22 to CaM is myristoylation dependent and the N-terminal myristoyl group is directly involved in the protein-protein interaction. Here we show the crystal structure of Ca2+-CaM bound to a myristoylated peptide corresponding to the N-terminal domain of CAP-23/NAP-22. The myristoyl moiety of the peptide goes through a hydrophobic tunnel created by the hydrophobic pockets in the N- and C-terminal domains of CaM. In addition to the myristoyl group, several amino-acid residues in the peptide are important for CaM binding. This is a novel mode of binding and is very different from the mechanism of binding in other CaM-target complexes.
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(as it appears on PubMed at http://www.pubmed.gov), where 14765114 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14765114}}
==About this Structure==
==About this Structure==
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[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:38:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:54:37 2008''

Revision as of 08:54, 2 July 2008

Image:1l7z.png

Template:STRUCTURE 1l7z

Crystal structure of Ca2+/Calmodulin complexed with myristoylated CAP-23/NAP-22 peptide

Template:ABSTRACT PUBMED 14765114

About this Structure

1L7Z is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a myristoylated CAP-23/NAP-22 N-terminal domain complexed with Ca2+/calmodulin., Matsubara M, Nakatsu T, Kato H, Taniguchi H, EMBO J. 2004 Feb 25;23(4):712-8. Epub 2004 Feb 12. PMID:14765114

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