1l8r

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{{STRUCTURE_1l8r| PDB=1l8r | SCENE= }}
{{STRUCTURE_1l8r| PDB=1l8r | SCENE= }}
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'''Structure of the Retinal Determination Protein Dachshund Reveals a DNA-Binding Motif'''
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===Structure of the Retinal Determination Protein Dachshund Reveals a DNA-Binding Motif===
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==Overview==
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The Dachshund proteins are essential components of a regulatory network controlling cell fate determination. They have been implicated in eye, limb, brain, and muscle development. These proteins cannot be assigned to any recognizable structural or functional class based on amino acid sequence analysis. The 1.65 A crystal structure of the most conserved domain of human DACHSHUND is reported here. The protein forms an alpha/beta structure containing a DNA binding motif similar to that found in the winged helix/forkhead subgroup of the helix-turn-helix family. This unexpected finding alters the previously proposed molecular models for the role of Dachshund in the eye determination pathway. Furthermore, it provides a rational framework for future mechanistic analyses of the Dachshund proteins in several developmental contexts.
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(as it appears on PubMed at http://www.pubmed.gov), where 12057194 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12057194}}
==About this Structure==
==About this Structure==
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[[Category: Zhang, R.]]
[[Category: Zhang, R.]]
[[Category: Winged-helix]]
[[Category: Winged-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:58:05 2008''

Revision as of 08:58, 2 July 2008

Image:1l8r.png

Template:STRUCTURE 1l8r

Structure of the Retinal Determination Protein Dachshund Reveals a DNA-Binding Motif

Template:ABSTRACT PUBMED 12057194

About this Structure

1L8R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the retinal determination protein Dachshund reveals a DNA binding motif., Kim SS, Zhang RG, Braunstein SE, Joachimiak A, Cvekl A, Hegde RS, Structure. 2002 Jun;10(6):787-95. PMID:12057194

Page seeded by OCA on Wed Jul 2 11:58:05 2008

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