1l9u

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[[Image:1l9u.gif|left|200px]]
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{{Seed}}
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[[Image:1l9u.png|left|200px]]
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{{STRUCTURE_1l9u| PDB=1l9u | SCENE= }}
{{STRUCTURE_1l9u| PDB=1l9u | SCENE= }}
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'''THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME AT 4 A RESOLUTION'''
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===THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME AT 4 A RESOLUTION===
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==Overview==
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The crystal structure of the initiating form of Thermus aquaticus RNA polymerase, containing core RNA polymerase (alpha2betabeta'omega) and the promoter specificity sigma subunit, has been determined at 4 angstrom resolution. Important structural features of the RNA polymerase and their roles in positioning sigma within the initiation complex are delineated, as well as the role played by sigma in modulating the opening of the RNA polymerase active-site channel. The two carboxyl-terminal domains of sigma are separated by 45 angstroms on the surface of the RNA polymerase, but are linked by an extended loop. The loop winds near the RNA polymerase active site, where it may play a role in initiating nucleotide substrate binding, and out through the RNA exit channel. The advancing RNA transcript must displace the loop, leading to abortive initiation and ultimately to sigma release.
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(as it appears on PubMed at http://www.pubmed.gov), where 12016306 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12016306}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:03:33 2008''

Revision as of 09:03, 2 July 2008

Image:1l9u.png

Template:STRUCTURE 1l9u

THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME AT 4 A RESOLUTION

Template:ABSTRACT PUBMED 12016306

About this Structure

1L9U is a Protein complex structure of sequences from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

Structural basis of transcription initiation: RNA polymerase holoenzyme at 4 A resolution., Murakami KS, Masuda S, Darst SA, Science. 2002 May 17;296(5571):1280-4. PMID:12016306

Page seeded by OCA on Wed Jul 2 12:03:33 2008

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