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1l9v

From Proteopedia

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{{STRUCTURE_1l9v| PDB=1l9v | SCENE= }}
{{STRUCTURE_1l9v| PDB=1l9v | SCENE= }}
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'''Non Structural protein encoded by gene segment 8 of rotavirus (NSP2), an NTPase, ssRNA binding and nucleic acid helix-destabilizing protein'''
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===Non Structural protein encoded by gene segment 8 of rotavirus (NSP2), an NTPase, ssRNA binding and nucleic acid helix-destabilizing protein===
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==Overview==
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Rotavirus, the major cause of life-threatening infantile gastroenteritis, is a member of the Reoviridae. Although the structures of rotavirus and other members of the Reoviridae have been extensively studied, little is known about the structures of virus-encoded non-structural proteins that are essential for genome replication and packaging. The non-structural protein NSP2 of rotavirus, which exhibits nucleoside triphosphatase, single-stranded RNA binding, and nucleic-acid helix-destabilizing activities, is a major component of viral replicase complexes. We present here the X-ray structure of the functional octamer of NSP2 determined to a resolution of 2.6 A. The NSP2 monomer has two distinct domains. The amino-terminal domain has a new fold. The carboxy-terminal domain resembles the ubiquitous cellular histidine triad (HIT) group of nucleotidyl hydrolases. This structural similarity suggests that the nucleotide-binding site is located inside the cleft between the two domains. Prominent grooves that run diagonally across the doughnut-shaped octamer are probable locations for RNA binding. Several RNA binding sites, resulting from the quaternary organization of NSP2 monomers, may be required for the helix destabilizing activity of NSP2 and its function during genome replication and packaging.
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(as it appears on PubMed at http://www.pubmed.gov), where 12015608 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12015608}}
==About this Structure==
==About this Structure==
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[[Category: Octamer]]
[[Category: Octamer]]
[[Category: Two domain protein]]
[[Category: Two domain protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:42:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:03:54 2008''

Revision as of 09:04, 2 July 2008

Image:1l9v.png

Template:STRUCTURE 1l9v

Non Structural protein encoded by gene segment 8 of rotavirus (NSP2), an NTPase, ssRNA binding and nucleic acid helix-destabilizing protein

Template:ABSTRACT PUBMED 12015608

About this Structure

1L9V is a Single protein structure of sequence from Simian 11 rotavirus a. Full crystallographic information is available from OCA.

Reference

Rotavirus protein involved in genome replication and packaging exhibits a HIT-like fold., Jayaram H, Taraporewala Z, Patton JT, Prasad BV, Nature. 2002 May 16;417(6886):311-5. PMID:12015608

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