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1lat

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[[Image:1lat.gif|left|200px]]
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{{STRUCTURE_1lat| PDB=1lat | SCENE= }}
{{STRUCTURE_1lat| PDB=1lat | SCENE= }}
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'''GLUCOCORTICOID RECEPTOR MUTANT/DNA COMPLEX'''
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===GLUCOCORTICOID RECEPTOR MUTANT/DNA COMPLEX===
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==Overview==
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Steroid receptors recognize bipartite targets composed of six base-pair half-sites. There are two canonical types of half-site which differ only in their central two base pairs. The crystal structure of an estrogen receptor-like DNA-binding domain bound to the wrong type of half-site (a glucocorticoid response element) reveals an interface that resembles the specific interfaces of the glucocorticoid receptor or estrogen receptor bound to their correct response elements. The underlying stereochemical defect that weakens the non-cognate interface is a difference in the helical geometry of the incorrect DNA half-site which prevents a side-chain contact and results in a gap which is filled by at least five additional fixed water sites, imposing a potential entropic burden on the stability of the interface.
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The line below this paragraph, {{ABSTRACT_PUBMED_7664096}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7664096 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7664096}}
==About this Structure==
==About this Structure==
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[[Category: Dna binding regulatory protein]]
[[Category: Dna binding regulatory protein]]
[[Category: Glucocorticoid receptor]]
[[Category: Glucocorticoid receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:43:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:08:43 2008''

Revision as of 09:08, 2 July 2008

Image:1lat.png

Template:STRUCTURE 1lat

GLUCOCORTICOID RECEPTOR MUTANT/DNA COMPLEX

Template:ABSTRACT PUBMED 7664096

About this Structure

1LAT is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The basis for half-site specificity explored through a non-cognate steroid receptor-DNA complex., Gewirth DT, Sigler PB, Nat Struct Biol. 1995 May;2(5):386-94. PMID:7664096

Page seeded by OCA on Wed Jul 2 12:08:43 2008

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