1lb7

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{{Seed}}
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{{STRUCTURE_1lb7| PDB=1lb7 | SCENE= }}
{{STRUCTURE_1lb7| PDB=1lb7 | SCENE= }}
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'''IGF-F1-1, A PEPTIDE ANTAGONIST OF IGF-1'''
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===IGF-F1-1, A PEPTIDE ANTAGONIST OF IGF-1===
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==Overview==
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A panel of 22 naive peptide libraries was constructed in a polyvalent phage display format and sorted against insulin-like growth factor-1 (IGF-1). The libraries were pooled to achieve a total diversity of 4.4 x 10(11). After three rounds of selection, the majority of the phage clones bound specifically to IGF-1, with a disulfide-constrained CX(9)C scaffold dominating the selection. Four monovalently displayed sub-libraries were designed on the basis of these conserved motifs. Sub-library maturation in a monovalent format yielded an antagonistic peptide that inhibited the interactions between IGF-1 and two cell-surface receptors and those between IGF-1 and two soluble IGF binding proteins with micromolar potency. NMR analysis revealed that the peptide is highly structured in the absence of IGF-1, and peptides that preorganize the binding elements were selected during the sorting.
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(as it appears on PubMed at http://www.pubmed.gov), where 11983338 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11983338}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB7 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB7 OCA].
==Reference==
==Reference==
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[[Category: Loop-helix]]
[[Category: Loop-helix]]
[[Category: Peptide]]
[[Category: Peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:44:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:12:35 2008''

Revision as of 09:12, 2 July 2008

Image:1lb7.png

Template:STRUCTURE 1lb7

IGF-F1-1, A PEPTIDE ANTAGONIST OF IGF-1

Template:ABSTRACT PUBMED 11983338

About this Structure

Full experimental information is available from OCA.

Reference

Rapid identification of small binding motifs with high-throughput phage display: discovery of peptidic antagonists of IGF-1 function., Deshayes K, Schaffer ML, Skelton NJ, Nakamura GR, Kadkhodayan S, Sidhu SS, Chem Biol. 2002 Apr;9(4):495-505. PMID:11983338

Page seeded by OCA on Wed Jul 2 12:12:35 2008

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