1lbi

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[[Image:1lbi.jpg|left|200px]]
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{{STRUCTURE_1lbi| PDB=1lbi | SCENE= }}
{{STRUCTURE_1lbi| PDB=1lbi | SCENE= }}
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'''LAC REPRESSOR'''
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===LAC REPRESSOR===
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==Overview==
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The lac operon of Escherichia coli is the paradigm for gene regulation. Its key component is the lac repressor, a product of the lacI gene. The three-dimensional structures of the intact lac repressor, the lac repressor bound to the gratuitous inducer isopropyl-beta-D-1-thiogalactoside (IPTG) and the lac repressor complexed with a 21-base pair symmetric operator DNA have been determined. These three structures show the conformation of the molecule in both the induced and repressed states and provide a framework for understanding a wealth of biochemical and genetic information. The DNA sequence of the lac operon has three lac repressor recognition sites in a stretch of 500 base pairs. The crystallographic structure of the complex with DNA suggests that the tetrameric repressor functions synergistically with catabolite gene activator protein (CAP) and participates in the quaternary formation of repression loops in which one tetrameric repressor interacts simultaneously with two sites on the genomic DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 8638105 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8638105}}
==About this Structure==
==About this Structure==
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[[Category: Repressor]]
[[Category: Repressor]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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Revision as of 09:14, 2 July 2008

Image:1lbi.png

Template:STRUCTURE 1lbi

LAC REPRESSOR

Template:ABSTRACT PUBMED 8638105

About this Structure

1LBI is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the lactose operon repressor and its complexes with DNA and inducer., Lewis M, Chang G, Horton NC, Kercher MA, Pace HC, Schumacher MA, Brennan RG, Lu P, Science. 1996 Mar 1;271(5253):1247-54. PMID:8638105

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