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1lc4

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{{STRUCTURE_1lc4| PDB=1lc4 | SCENE= }}
{{STRUCTURE_1lc4| PDB=1lc4 | SCENE= }}
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'''Crystal Structure of Tobramycin Bound to the Eubacterial 16S rRNA A Site'''
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===Crystal Structure of Tobramycin Bound to the Eubacterial 16S rRNA A Site===
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==Overview==
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Aminoglycoside antibiotics target the decoding aminoacyl site (A site) on the 16S ribosomal RNA and induce miscoding during translation. Here, we present the crystal structure, at 2.54 A resolution, of an RNA oligonucleotide containing the A site sequence complexed to the 4,6-disubstituted 2-deoxystreptamine aminoglycoside tobramycin. The three aminosugar rings making up tobramycin interact with the deep-groove atoms directly or via water molecules and stabilize a fully bulged-out conformation of adenines A(1492) and A(1493). The comparison between this structure and the one previously solved in the presence of paromomycin confirms the importance of the functional groups on the common neamine part of these two antibiotics for binding to RNA. Furthermore, the analysis of the present structure provides a molecular explanation to some of the resistance mechanisms that have spread among bacteria and rendered aminoglycoside antibiotics inefficient.
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{{ABSTRACT_PUBMED_12079787}}
==About this Structure==
==About this Structure==
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[[Category: Adenine bulge]]
[[Category: Adenine bulge]]
[[Category: Antibiotic-rna complex]]
[[Category: Antibiotic-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:46:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:19:12 2008''

Revision as of 09:19, 2 July 2008

Image:1lc4.png

Template:STRUCTURE 1lc4

Crystal Structure of Tobramycin Bound to the Eubacterial 16S rRNA A Site

Template:ABSTRACT PUBMED 12079787

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site., Vicens Q, Westhof E, Chem Biol. 2002 Jun;9(6):747-55. PMID:12079787

Page seeded by OCA on Wed Jul 2 12:19:12 2008

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