1lc6

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[[Image:1lc6.gif|left|200px]]
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{{STRUCTURE_1lc6| PDB=1lc6 | SCENE= }}
{{STRUCTURE_1lc6| PDB=1lc6 | SCENE= }}
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'''Solution Structure of the U6 Intramolecular Stem-loop RNA'''
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===Solution Structure of the U6 Intramolecular Stem-loop RNA===
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==Overview==
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U6 RNA is a key component of the catalytic core of the spliceosome. A metal ion essential for the first catalytic step of pre-mRNA splicing binds to the U80 Sp phosphate oxygen within the yeast U6 intramolecular stem-loop (ISL). Here we present the first structural data for U6 RNA, revealing the three-dimensional structure of the highly conserved U6 ISL. The ISL binds metal ion at the U80 site with the same stereo specificity as the intact spliceosome. The metal-binding site is adjacent to a readily protonated C.A wobble pair. Protonation of the C.A pair and metal binding are mutually antagonistic. These results support a ribozyme model for U6 RNA function and suggest a possible mechanism for the regulation of RNA splicing.
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The line below this paragraph, {{ABSTRACT_PUBMED_11992125}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11992125 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11992125}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LC6 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LC6 OCA].
==Reference==
==Reference==
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[[Category: Rna]]
[[Category: Rna]]
[[Category: Stem-loop]]
[[Category: Stem-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:46:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:19:13 2008''

Revision as of 09:19, 2 July 2008

Image:1lc6.png

Template:STRUCTURE 1lc6

Solution Structure of the U6 Intramolecular Stem-loop RNA

Template:ABSTRACT PUBMED 11992125

About this Structure

Full experimental information is available from OCA.

Reference

Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure., Huppler A, Nikstad LJ, Allmann AM, Brow DA, Butcher SE, Nat Struct Biol. 2002 Jun;9(6):431-5. PMID:11992125

Page seeded by OCA on Wed Jul 2 12:19:13 2008

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