1lcy

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{{STRUCTURE_1lcy| PDB=1lcy | SCENE= }}
{{STRUCTURE_1lcy| PDB=1lcy | SCENE= }}
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'''Crystal Structure of the Mitochondrial Serine Protease HtrA2'''
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===Crystal Structure of the Mitochondrial Serine Protease HtrA2===
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==Overview==
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HtrA2/Omi, a mitochondrial serine protease in mammals, is important in programmed cell death. However, the underlining mechanism of HtrA2/Omi-mediated apoptosis remains unclear. Analogous to the bacterial homolog HtrA (DegP), the mature HtrA2 protein contains a central serine protease domain and a C-terminal PDZ domain. The 2.0 A crystal structure of HtrA2/Omi reveals the formation of a pyramid-shaped homotrimer mediated exclusively by the serine protease domains. The peptide-binding pocket of the PDZ domain is buried in the intimate interface between the PDZ and the protease domains. Mutational analysis reveals that the monomeric HtrA2/Omi mutants are unable to induce cell death and are deficient in protease activity. The PDZ domain modulates HtrA2/Omi-mediated cell death activity by regulating its serine protease activity. These structural and biochemical observations provide an important framework for deciphering the mechanisms of HtrA2/Omi-mediated apoptosis.
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{{ABSTRACT_PUBMED_11967569}}
==About this Structure==
==About this Structure==
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[[Category: Pdz domain]]
[[Category: Pdz domain]]
[[Category: Serine protease]]
[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:47:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:25:16 2008''

Revision as of 09:25, 2 July 2008

Image:1lcy.png

Template:STRUCTURE 1lcy

Crystal Structure of the Mitochondrial Serine Protease HtrA2

Template:ABSTRACT PUBMED 11967569

About this Structure

1LCY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi., Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, Shi Y, Nat Struct Biol. 2002 Jun;9(6):436-41. PMID:11967569

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