1ld4

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[[Image:1ld4.gif|left|200px]]
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{{Seed}}
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[[Image:1ld4.png|left|200px]]
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{{STRUCTURE_1ld4| PDB=1ld4 | SCENE= }}
{{STRUCTURE_1ld4| PDB=1ld4 | SCENE= }}
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'''Placement of the Structural Proteins in Sindbis Virus'''
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===Placement of the Structural Proteins in Sindbis Virus===
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==Overview==
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The structure of the lipid-enveloped Sindbis virus has been determined by fitting atomic resolution crystallographic structures of component proteins into an 11-A resolution cryoelectron microscopy map. The virus has T=4 quasisymmetry elements that are accurately maintained between the external glycoproteins, the transmembrane helical region, and the internal nucleocapsid core. The crystal structure of the E1 glycoprotein was fitted into the cryoelectron microscopy density, in part by using the known carbohydrate positions as restraints. A difference map showed that the E2 glycoprotein was shaped similarly to E1, suggesting a possible common evolutionary origin for these two glycoproteins. The structure shows that the E2 glycoprotein would have to move away from the center of the trimeric spike in order to expose enough viral membrane surface to permit fusion with the cellular membrane during the initial stages of host infection. The well-resolved E1-E2 transmembrane regions form alpha-helical coiled coils that were consistent with T=4 symmetry. The known structure of the capsid protein was fitted into the density corresponding to the nucleocapsid, revising the structure published earlier.
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The line below this paragraph, {{ABSTRACT_PUBMED_12388725}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12388725 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12388725}}
==About this Structure==
==About this Structure==
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[[Category: Sindbis virus]]
[[Category: Sindbis virus]]
[[Category: Transmembrane coiled coil]]
[[Category: Transmembrane coiled coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:48:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:26:52 2008''

Revision as of 09:27, 2 July 2008

Image:1ld4.png

Template:STRUCTURE 1ld4

Placement of the Structural Proteins in Sindbis Virus

Template:ABSTRACT PUBMED 12388725

About this Structure

1LD4 is a Protein complex structure of sequences from Saccharomyces cerevisiae and Sindbis virus. Full crystallographic information is available from OCA.

Reference

Placement of the structural proteins in Sindbis virus., Zhang W, Mukhopadhyay S, Pletnev SV, Baker TS, Kuhn RJ, Rossmann MG, J Virol. 2002 Nov;76(22):11645-58. PMID:12388725

Page seeded by OCA on Wed Jul 2 12:26:52 2008

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