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1at3
From Proteopedia
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(New page: 200px<br /> <applet load="1at3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1at3, resolution 2.5Å" /> '''HERPES SIMPLEX VIRUS...)
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Revision as of 17:56, 29 October 2007
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HERPES SIMPLEX VIRUS TYPE II PROTEASE
Overview
Human herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are, responsible for herpes labialis (cold sores) and genital herpes, respectively. They encode a serine protease that is required for viral, replication, and represent a viable target for therapeutic intervention., Here, we report the crystal structures of HSV-1 and HSV-2 proteases, the, latter in the presence and absence of the covalently bound transition, state analog inhibitor diisopropyl phosphate (DIP). The HSV-1 and HSV-2, protease structures show a fold that is neither like chymotrypsin nor like, subtilisin, and has been seen only in the recently determined, cytomegalovirus (CMV) and varicella-zoster virus (VZV) protease, structures. HSV-1 and HSV-2 proteases share high sequence homology and, have almost identical ... [(full description)]
About this Structure
1AT3 is a [Single protein] structure of sequence from [Human herpesvirus 2] with DFP as [ligand]. Full crystallographic information is available from [OCA].
Reference
Active site cavity of herpesvirus proteases revealed by the crystal structure of herpes simplex virus protease/inhibitor complex., Hoog SS, Smith WW, Qiu X, Janson CA, Hellmig B, McQueney MS, O'Donnell K, O'Shannessy D, DiLella AG, Debouck C, Abdel-Meguid SS, Biochemistry. 1997 Nov 18;36(46):14023-9. PMID:9369473
Page seeded by OCA on Mon Oct 29 20:00:51 2007
