1lf1

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[[Image:1lf1.gif|left|200px]]
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{{STRUCTURE_1lf1| PDB=1lf1 | SCENE= }}
{{STRUCTURE_1lf1| PDB=1lf1 | SCENE= }}
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'''Crystal Structure of Cel5 from Alkalophilic Bacillus sp.'''
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===Crystal Structure of Cel5 from Alkalophilic Bacillus sp.===
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==Overview==
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The crystal structure of an alkaline Bacillus cellulase catalytic core, from glucoside hydrolase family 5, reveals a novel combination of the catalytic machinery of two classic textbook enzymes. The enzyme has the expected two glutamate residues in close proximity to one another in the active-site that are typical of retaining cellulases. However, the proton donor, glutamate 139 is also unexpectedly a member of a serine-histidine-glutamate catalytic triad, forming a novel combination of catalytic machineries. Structure and sequence analysis of glucoside hydrolase family 5 reveal that the triad is highly conserved, but with variations at the equivalent of the serine position. We speculate that the purpose of this novel catalytic triad is to control the protonation of the acid/base glutamate, facilitating the first step of the catalytic reaction, protonation of the substrate, by the proton donor glutamate. If correct, this will be a novel use for a catalytic triad.
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(as it appears on PubMed at http://www.pubmed.gov), where 12079387 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12079387}}
==About this Structure==
==About this Structure==
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[[Category: Vonrhein, C.]]
[[Category: Vonrhein, C.]]
[[Category: Cellulose degradation]]
[[Category: Cellulose degradation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:51:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 17:10:58 2008''

Revision as of 14:31, 2 July 2008

Image:1lf1.png

Template:STRUCTURE 1lf1

Crystal Structure of Cel5 from Alkalophilic Bacillus sp.

Template:ABSTRACT PUBMED 12079387

About this Structure

1LF1 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

A novel combination of two classic catalytic schemes., Shaw A, Bott R, Vonrhein C, Bricogne G, Power S, Day AG, J Mol Biol. 2002 Jul 5;320(2):303-9. PMID:12079387

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