1lf8

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[[Image:1lf8.gif|left|200px]]
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{{STRUCTURE_1lf8| PDB=1lf8 | SCENE= }}
{{STRUCTURE_1lf8| PDB=1lf8 | SCENE= }}
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'''Complex of GGA3-VHS Domain and CI-MPR C-terminal Phosphopeptide'''
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===Complex of GGA3-VHS Domain and CI-MPR C-terminal Phosphopeptide===
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==Overview==
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Phosphorylation of the cytosolic tails of transmembrane receptors can regulate their intracellular trafficking. The structural basis for such regulation, however, has not been explained in most cases. The cytosolic tail of the cation-independent mannose 6-phosphate receptor contains a serine residue within an acidic-cluster dileucine signal that is important for the function of the receptor in the biosynthetic sorting of lysosomal hydrolases. We show here that phosphorylation of this Ser enhances interactions of the signal with its recognition module, the VHS domain of the GGA proteins. Crystallographic analyses demonstrate that the phosphoserine residue interacts electrostatically with two basic residues on the VHS domain of GGA3, thus providing an additional point of attachment of the acidic-cluster dileucine signal to its recognition module.
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(as it appears on PubMed at http://www.pubmed.gov), where 12032548 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12032548}}
==About this Structure==
==About this Structure==
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[[Category: Protein-phosphopeptide complex]]
[[Category: Protein-phosphopeptide complex]]
[[Category: Vhs domain]]
[[Category: Vhs domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:52:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 18:36:11 2008''

Revision as of 15:40, 2 July 2008

Image:1lf8.png

Template:STRUCTURE 1lf8

Complex of GGA3-VHS Domain and CI-MPR C-terminal Phosphopeptide

Template:ABSTRACT PUBMED 12032548

About this Structure

1LF8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism., Kato Y, Misra S, Puertollano R, Hurley JH, Bonifacino JS, Nat Struct Biol. 2002 Jul;9(7):532-6. PMID:12032548

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