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1lfd

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{{STRUCTURE_1lfd| PDB=1lfd | SCENE= }}
{{STRUCTURE_1lfd| PDB=1lfd | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE ACTIVE RAS PROTEIN COMPLEXED WITH THE RAS-INTERACTING DOMAIN OF RALGDS'''
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===CRYSTAL STRUCTURE OF THE ACTIVE RAS PROTEIN COMPLEXED WITH THE RAS-INTERACTING DOMAIN OF RALGDS===
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==Overview==
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The Ras protein signals to a number of distinct pathways by interacting with diverse downstream effectors. Among the effectors of Ras are the Raf kinase and RalGDS, a guanine nucleotide dissociation stimulator specific for Ral. Despite the absence of significant sequence similarities, both effectors bind directly to Ras, but with different specificities. We report here the 2.1 A crystal structure of the complex between Ras and the Ras-interacting domain (RID) of RalGDS. This structure reveals that the beta-sheet of the RID joins the switch I region of Ras to form an extended beta-sheet with a topology similar to that found in the Rap-Raf complex. However, the side chain interactions at the joining junctions of the two interacting systems and the relative orientation of the two binding domains are distinctly different. Furthermore, in the case of the Ras-RID complex a second RID molecule also interacts with a different part of the Ras molecule, the switch II region. These findings account for the cross-talk between the Ras and Ral pathways and the specificity with which Ras distinguishes the two effectors.
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(as it appears on PubMed at http://www.pubmed.gov), where 9628477 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9628477}}
==About this Structure==
==About this Structure==
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[[Category: Effector interaction]]
[[Category: Effector interaction]]
[[Category: Ral]]
[[Category: Ral]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:52:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 19:33:43 2008''

Revision as of 16:38, 2 July 2008

Image:1lfd.png

Template:STRUCTURE 1lfd

CRYSTAL STRUCTURE OF THE ACTIVE RAS PROTEIN COMPLEXED WITH THE RAS-INTERACTING DOMAIN OF RALGDS

Template:ABSTRACT PUBMED 9628477

About this Structure

1LFD is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural basis for the interaction of Ras with RalGDS., Huang L, Hofer F, Martin GS, Kim SH, Nat Struct Biol. 1998 Jun;5(6):422-6. PMID:9628477

Page seeded by OCA on Wed Jul 2 19:33:43 2008

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