1lfw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1lfw.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1lfw.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1lfw| PDB=1lfw | SCENE= }}
{{STRUCTURE_1lfw| PDB=1lfw | SCENE= }}
-
'''Crystal structure of pepV'''
+
===Crystal structure of pepV===
-
==Overview==
+
<!--
-
PepV from Lactobacillus delbrueckii, a dinuclear zinc peptidase, has been characterized as an unspecific amino dipeptidase. The crystal structure of PepV in complex with the phosphinic inhibitor AspPsi[PO(2)CH(2)]AlaOH, a dipeptide substrate mimetic, reveals a "catalytic domain" and a "lid domain," which together form an internal active site cavity that traps the inhibitor. The catalytic domain is topologically similar to catalytic domains from amino- and carboxypeptidases. However, the lid domain is unique among the related enzymes. In contrast to the other related exopeptidases, PepV recognizes and fixes the dipeptide backbone, while the side chains are not specifically probed and can vary, rendering it a nonspecific dipeptidase. The cocrystallized inhibitor illustrates the two roles of the two catalytic zinc ions, namely stabilization of the tetrahedral intermediate and activation of the catalytic water molecule.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12176387}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12176387 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12176387}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Dipeptidase]]
[[Category: Dipeptidase]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:53:00 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 20:51:07 2008''

Revision as of 17:51, 2 July 2008

Image:1lfw.png

Template:STRUCTURE 1lfw

Crystal structure of pepV

Template:ABSTRACT PUBMED 12176387

About this Structure

1LFW is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Crystal structure of the dinuclear zinc aminopeptidase PepV from Lactobacillus delbrueckii unravels its preference for dipeptides., Jozic D, Bourenkow G, Bartunik H, Scholze H, Dive V, Henrich B, Huber R, Bode W, Maskos K, Structure. 2002 Aug;10(8):1097-106. PMID:12176387

Page seeded by OCA on Wed Jul 2 20:51:07 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1lfw"
Personal tools