1lhp

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{{STRUCTURE_1lhp| PDB=1lhp | SCENE= }}
{{STRUCTURE_1lhp| PDB=1lhp | SCENE= }}
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'''Crystal Structure of Pyridoxal Kinase from Sheep Brain'''
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===Crystal Structure of Pyridoxal Kinase from Sheep Brain===
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==Overview==
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The three-dimensional structures of brain pyridoxal kinase and its complex with the nucleotide ATP have been elucidated in the dimeric form at 2.1 and 2.6 A, respectively. Results have shown that pyridoxal kinase, as an enzyme obeying random sequential kinetics in catalysis, does not possess a lid shape structure common to all kinases in the ribokinase superfamily. This finding has been shown to be in line with the condition that pyridoxal kinase binds substrates with variable sizes of chemical groups at position 4 of vitamin B(6) and its derivatives. In addition, the enzyme contains a 12-residue peptide loop in the active site for the prevention of premature hydrolysis of ATP. Conserved amino acid residues Asp(118) and Tyr(127) in the peptide loop could be moved to a position covering the nucleotide after its binding so that its chance to hydrolyze in the aqueous environment of the active site was reduced. With respect to the evolutionary trend of kinase enzymes, the existence of this loop in pyridoxal kinase could be classified as an independent category in the ribokinase superfamily according to the structural feature found and mechanism followed in catalysis.
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The line below this paragraph, {{ABSTRACT_PUBMED_12235162}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12235162 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12235162}}
==About this Structure==
==About this Structure==
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[[Category: Liang, D C.]]
[[Category: Liang, D C.]]
[[Category: Alpha-beta structure]]
[[Category: Alpha-beta structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:55:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 20:56:20 2008''

Revision as of 17:56, 2 July 2008

Image:1lhp.png

Template:STRUCTURE 1lhp

Crystal Structure of Pyridoxal Kinase from Sheep Brain

Template:ABSTRACT PUBMED 12235162

About this Structure

1LHP is a Single protein structure of sequence from Ovis aries. Full crystallographic information is available from OCA.

Reference

Crystal structure of brain pyridoxal kinase, a novel member of the ribokinase superfamily., Li MH, Kwok F, Chang WR, Lau CK, Zhang JP, Lo SC, Jiang T, Liang DC, J Biol Chem. 2002 Nov 29;277(48):46385-90. Epub 2002 Sep 15. PMID:12235162

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