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1lin

From Proteopedia

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[[Image:1lin.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1lin| PDB=1lin | SCENE= }}
{{STRUCTURE_1lin| PDB=1lin | SCENE= }}
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'''CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:4 COMPLEX)'''
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===CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:4 COMPLEX)===
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==Overview==
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Here we show that, as a consequence of binding the drug trifluoperazine, a major conformational movement occurs in Ca(2+)-calmodulin (CaM). The tertiary structure changes from an elongated dumb-bell, with exposed hydrophobic surfaces, to a compact globular form which can no longer interact with its target enzymes. It is likely that inactivation of Ca(2+)-CaM by trifluoperazine is due to this major tertiary-structural alteration in Ca(2+)-CaM, which is initiated and stabilized by drug binding. This conformational change is similar to that which occurs on the binding of Ca(2+)-CaM to target peptides. Two hydrophobic binding pockets, created by amino acid residues adjacent to Ca(2+)-coordinating residues, form the key recognition sites on Ca(2+)-CaM for both inhibitors and target enzymes.
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The line below this paragraph, {{ABSTRACT_PUBMED_7634090}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7634090 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7634090}}
==About this Structure==
==About this Structure==
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[[Category: Vandonselaar, M.]]
[[Category: Vandonselaar, M.]]
[[Category: Calcium-binding protein]]
[[Category: Calcium-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:57:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 20:59:06 2008''

Revision as of 17:59, 2 July 2008

Image:1lin.png

Template:STRUCTURE 1lin

CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:4 COMPLEX)

Template:ABSTRACT PUBMED 7634090

About this Structure

1LIN is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Trifluoperazine-induced conformational change in Ca(2+)-calmodulin., Vandonselaar M, Hickie RA, Quail JW, Delbaere LT, Nat Struct Biol. 1994 Nov;1(11):795-801. PMID:7634090

Page seeded by OCA on Wed Jul 2 20:59:06 2008

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