1liq

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[[Image:1liq.gif|left|200px]]
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{{Seed}}
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[[Image:1liq.png|left|200px]]
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{{STRUCTURE_1liq| PDB=1liq | SCENE= }}
{{STRUCTURE_1liq| PDB=1liq | SCENE= }}
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'''Non-native Solution Structure of a fragment of the CH1 domain of CBP'''
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===Non-native Solution Structure of a fragment of the CH1 domain of CBP===
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==Overview==
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Many different zinc binding modules have been identified. Their abundance and variety suggests that the formation of zinc binding folds might be relatively common. We have determined the structure of CH1(1), a 27-residue peptide derived from the first cysteine/histidine-rich region (CH1) of CREB binding protein (CBP). This peptide forms a highly ordered zinc-dependent fold that is distinct from known folds. The structure differs from a subsequently determined structure of a larger region from the CH3 region of CBP, and the CH1(1) fold probably represents a nonphysiologically active form. Despite this, the fold is thermostable and tolerant to both multiple alanine mutations and changes in the zinc-ligand spacing. Our data support the idea that zinc binding domains may arise frequently. Additionally, such structures may prove useful as scaffolds for protein design, given their stability and robustness.
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The line below this paragraph, {{ABSTRACT_PUBMED_12015147}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12015147 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12015147}}
==About this Structure==
==About this Structure==
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1LIQ is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LIQ OCA].
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1LIQ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LIQ OCA].
==Reference==
==Reference==
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[[Category: Protein design]]
[[Category: Protein design]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:57:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 20:59:22 2008''

Revision as of 17:59, 2 July 2008

Image:1liq.png

Template:STRUCTURE 1liq

Non-native Solution Structure of a fragment of the CH1 domain of CBP

Template:ABSTRACT PUBMED 12015147

About this Structure

1LIQ is a Single protein structure. Full experimental information is available from OCA.

Reference

A new zinc binding fold underlines the versatility of zinc binding modules in protein evolution., Sharpe BK, Matthews JM, Kwan AH, Newton A, Gell DA, Crossley M, Mackay JP, Structure. 2002 May;10(5):639-48. PMID:12015147

Page seeded by OCA on Wed Jul 2 20:59:22 2008

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