1lir

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[[Image:1lir.gif|left|200px]]
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{{Seed}}
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[[Image:1lir.png|left|200px]]
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{{STRUCTURE_1lir| PDB=1lir | SCENE= }}
{{STRUCTURE_1lir| PDB=1lir | SCENE= }}
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'''LQ2 FROM LEIURUS QUINQUESTRIATUS, NMR, 22 STRUCTURES'''
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===LQ2 FROM LEIURUS QUINQUESTRIATUS, NMR, 22 STRUCTURES===
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==Overview==
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Lq2 is a unique scorpion toxin. Acting from the extracellular side, Lq2 blocks the ion conduction pore in not only the voltage- and Ca2+ -activated channels, but also the inward-rectifier K+ channels. This finding argues that the three-dimensional structures of the pores in these K+ channels are similar. However, the amino acid sequences that form the external part of the pore are minimally conserved among the various classes of K+ channels. Because Lq2 can bind to all the three classes of K+ channels, we can use Lq2 as a structural probe to examine how the non-conserved pore-forming sequences are arranged in space to form similar pore structures. In the present study, we determined the three-dimensional structure of Lq2 using nuclear magnetic resonance (NMR) techniques. Lq2 consists of an alpha-helix (residues S10 to L20) and a beta-sheet, connected by an alphabeta3 loop (residues N22 to N24). The beta-sheet has two well-defined anti-parallel strands (residues G26 to M29 and residues K32 to C35), which are connected by a type I' beta-turn centered between residues N30 and K31. The N-terminal segment (residues Z1 to T8) appears to form a quasi-third strand of the beta-sheet.
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(as it appears on PubMed at http://www.pubmed.gov), where 10081954 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10081954}}
==About this Structure==
==About this Structure==
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1LIR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus_hebraeus Leiurus quinquestriatus hebraeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LIR OCA].
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1LIR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus_hebraeus Leiurus quinquestriatus hebraeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LIR OCA].
==Reference==
==Reference==
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[[Category: Potassium channel blocker]]
[[Category: Potassium channel blocker]]
[[Category: Scorpion]]
[[Category: Scorpion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:57:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 20:59:30 2008''

Revision as of 17:59, 2 July 2008

Image:1lir.png

Template:STRUCTURE 1lir

LQ2 FROM LEIURUS QUINQUESTRIATUS, NMR, 22 STRUCTURES

Template:ABSTRACT PUBMED 10081954

About this Structure

1LIR is a Single protein structure of sequence from Leiurus quinquestriatus hebraeus. Full experimental information is available from OCA.

Reference

Solution structure of potassium channel-inhibiting scorpion toxin Lq2., Renisio JG, Lu Z, Blanc E, Jin W, Lewis JH, Bornet O, Darbon H, Proteins. 1999 Mar 1;34(4):417-26. PMID:10081954

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