2a9l
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(New page: 200px<br /> <applet load="2a9l" size="450" color="white" frame="true" align="right" spinBox="true" caption="2a9l" /> '''SOLUTION NMR STRUCTURE OF A SUBSTRATE FOR T...)
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Revision as of 17:56, 29 October 2007
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SOLUTION NMR STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, MINIMIZED AVERAGE STRUCTURE
Overview
The structure of the bulge-helix-bulge motif that constitutes the, intron/exon splice site in H. volcanii pre-tRNATrp has been determined by, NMR spectroscopy. The conformations of the two 3 nt bulges, where the, pre-tRNA is cleaved, are stabilized by stacking interactions between bulge, nucleotides and bases in the adjacent Watson-Crick helices and by a, network of backbone hydrogen bonds. Both bulges are presented on the same, minor groove face of the central 4 bp helix, and the overall structure has, approximate two-fold symmetry, which makes it well-suited for attack by, archaeal splicing endonucleases, which are symmetric dimers.
About this Structure
2A9L is a [Protein complex] structure of sequences from [[1]]. Full crystallographic information is available from [OCA].
Reference
Solution structure of a substrate for the archaeal pre-tRNA splicing endonucleases: the bulge-helix-bulge motif., Diener JL, Moore PB, Mol Cell. 1998 May;1(6):883-94. PMID:9660971
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