1lk2

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[[Image:1lk2.gif|left|200px]]
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{{STRUCTURE_1lk2| PDB=1lk2 | SCENE= }}
{{STRUCTURE_1lk2| PDB=1lk2 | SCENE= }}
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'''1.35A crystal structure of H-2Kb complexed with the GNYSFYAL peptide'''
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===1.35A crystal structure of H-2Kb complexed with the GNYSFYAL peptide===
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==Overview==
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We identify and consider some characteristics of a peptide antagonist for the Ag-specific receptor on 2C cells (the 2C TCR). The peptide, GNYSFYAL (called GNY), binds to H-2K(b), and a very high-resolution crystal structure of the GNY-K(b) complex at 1.35 A is described. Although the GNY peptide does not bind to L(d), the potency of GNY-K(b) as an antagonist is evident from its ability to specifically inhibit 2C TCR-mediated reactions to an allogenic agonist complex (QLSPFPFDL-L(d)), as well as to a syngeneic agonist complex (SIYRYYGL-K(b)). The crystal structure and the activities of alanine-substituted peptide variants point to the properties of the peptide P4 side chain and the conformation of the Tyr-P6 side chain as the structural determinants of GNYSFYAL antagonist activity.
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The line below this paragraph, {{ABSTRACT_PUBMED_14978103}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14978103 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14978103}}
==About this Structure==
==About this Structure==
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[[Category: Class i mhc-peptide complex]]
[[Category: Class i mhc-peptide complex]]
[[Category: High resolution]]
[[Category: High resolution]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:59:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:16:37 2008''

Revision as of 18:16, 2 July 2008

Image:1lk2.png

Template:STRUCTURE 1lk2

1.35A crystal structure of H-2Kb complexed with the GNYSFYAL peptide

Template:ABSTRACT PUBMED 14978103

About this Structure

1LK2 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects., Rudolph MG, Shen LQ, Lamontagne SA, Luz JG, Delaney JR, Ge Q, Cho BK, Palliser D, McKinley CA, Chen J, Wilson IA, Eisen HN, J Immunol. 2004 Mar 1;172(5):2994-3002. PMID:14978103

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