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1llm

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[[Image:1llm.jpg|left|200px]]
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{{STRUCTURE_1llm| PDB=1llm | SCENE= }}
{{STRUCTURE_1llm| PDB=1llm | SCENE= }}
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'''Crystal Structure of a Zif23-GCN4 Chimera Bound to DNA'''
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===Crystal Structure of a Zif23-GCN4 Chimera Bound to DNA===
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==Overview==
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Proteins that employ dimerization domains to bind cooperatively to DNA have a number of potential advantages over monomers with regards to gene regulation. Using a combination of structure-based design and phage display, a dimeric Cys(2)His(2) zinc finger protein has been created that binds cooperatively to DNA via an attached leucine zipper dimerization domain. This chimera, derived from components of Zif268 and GCN4, displayed excellent DNA-binding specificity, and we now report the 1.5 A resolution cocrystal structure of the Zif268-GCN4 homodimer bound to DNA. This structure shows how phage display has annealed the DNA binding and dimerization domains into a single functional unit. Moreover, this chimera provides a potential platform for the creation heterodimeric zinc finger proteins that can regulate a desired target gene through cooperative DNA recognition.
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(as it appears on PubMed at http://www.pubmed.gov), where 14621985 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14621985}}
==About this Structure==
==About this Structure==
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[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:02:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:22:46 2008''

Revision as of 18:22, 2 July 2008

Image:1llm.png

Template:STRUCTURE 1llm

Crystal Structure of a Zif23-GCN4 Chimera Bound to DNA

Template:ABSTRACT PUBMED 14621985

About this Structure

1LLM is a Single protein structure of sequence from Mus musculus and saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of a designed dimeric zinc finger protein bound to DNA., Wolfe SA, Grant RA, Pabo CO, Biochemistry. 2003 Nov 25;42(46):13401-9. PMID:14621985

Page seeded by OCA on Wed Jul 2 21:22:46 2008

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