2qh2

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[[Image:2qh2.gif|left|200px]]
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{{STRUCTURE_2qh2| PDB=2qh2 | SCENE= }}
{{STRUCTURE_2qh2| PDB=2qh2 | SCENE= }}
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'''Solution structure of the CR7 terminal hairpin loop from human telomerase RNA'''
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===Solution structure of the CR7 terminal hairpin loop from human telomerase RNA===
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==Overview==
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The RNA component of human telomerase (hTR) includes H/ACA and CR7 domains required for 3' end processing, localization, and accumulation. The terminal loop of the CR7 domain contains the CAB box (ugAG) required for targeting of scaRNAs to Cajal bodies (CB) and an uncharacterized sequence required for accumulation and processing. To dissect out the contributions of the CR7 stem loop to hTR processing and localization, we solved the solution structures of the 3' terminal stem loops of hTR CR7 and U64 H/ACA snoRNA, and the 5' terminal stem loop of U85 C/D-H/ACA scaRNA. These structures, together with analysis of localization, processing, and accumulation of hTRs containing nucleotide substitutions in the CR7 domain, identified the sequence and structural requirements of the hTR processing and CB localization signals and showed that these signals are functionally independent. Further, 3' end processing was found to be a prerequisite for translocation of hTR to CBs.
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The line below this paragraph, {{ABSTRACT_PUBMED_17889661}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17889661 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17889661}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QH2 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QH2 OCA].
==Reference==
==Reference==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:57:24 2008''
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Revision as of 18:26, 2 July 2008

Image:2qh2.png

Template:STRUCTURE 2qh2

Solution structure of the CR7 terminal hairpin loop from human telomerase RNA

Template:ABSTRACT PUBMED 17889661

About this Structure

Full experimental information is available from OCA.

Reference

Structural and functional characterization of human telomerase RNA processing and cajal body localization signals., Theimer CA, Jady BE, Chim N, Richard P, Breece KE, Kiss T, Feigon J, Mol Cell. 2007 Sep 21;27(6):869-81. PMID:17889661

Page seeded by OCA on Wed Jul 2 21:26:03 2008

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