1lnl

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[[Image:1lnl.gif|left|200px]]
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{{STRUCTURE_1lnl| PDB=1lnl | SCENE= }}
{{STRUCTURE_1lnl| PDB=1lnl | SCENE= }}
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'''Structure of deoxygenated hemocyanin from Rapana thomasiana'''
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===Structure of deoxygenated hemocyanin from Rapana thomasiana===
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==Overview==
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Structure-function relationships in a molluscan hemocyanin have been investigated by determining the crystal structure of the Rapana thomasiana (gastropod) hemocyanin functional unit RtH2e in deoxygenated form at 3.38 A resolution. This is the first X-ray structure of an unit from the wall of the molluscan hemocyanin cylinder. The crystal structure of RtH2e demonstrates molecular self-assembly of six identical molecules forming a regular hexameric cylinder. This suggests how the functional units are ordered in the wall of the native molluscan hemocyanins. The molecular arrangement is stabilized by specific protomer-to-protomer interactions, which are probably typical for the functional units building the wall of the cylinders. A molecular mechanism for cooperative dioxygen binding in molluscan hemocyanins is proposed on the basis of the molecular interactions between the protomers. In particular, the deoxygenated RtH2e structure reveals a tunnel leading from two opposite sides of the molecule to the active site. The tunnel represents a possible entrance pathway for dioxygen molecules. No such tunnels have been observed in the crystal structure of the oxy-Odg, a functional unit from the Octopus dofleini (cephalopod) hemocyanin in oxygenated form.
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(as it appears on PubMed at http://www.pubmed.gov), where 12767214 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12767214}}
==About this Structure==
==About this Structure==
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[[Category: Metal binding site]]
[[Category: Metal binding site]]
[[Category: Oxygen]]
[[Category: Oxygen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:05:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:30:34 2008''

Revision as of 18:30, 2 July 2008

Image:1lnl.png

Template:STRUCTURE 1lnl

Structure of deoxygenated hemocyanin from Rapana thomasiana

Template:ABSTRACT PUBMED 12767214

About this Structure

1LNL is a Single protein structure of sequence from Rapana thomasiana. Full crystallographic information is available from OCA.

Reference

The structure of a functional unit from the wall of a gastropod hemocyanin offers a possible mechanism for cooperativity., Perbandt M, Guthohrlein EW, Rypniewski W, Idakieva K, Stoeva S, Voelter W, Genov N, Betzel C, Biochemistry. 2003 Jun 3;42(21):6341-6. PMID:12767214

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