1lo5

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[[Image:1lo5.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1lo5| PDB=1lo5 | SCENE= }}
{{STRUCTURE_1lo5| PDB=1lo5 | SCENE= }}
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'''Crystal structure of the D227A variant of Staphylococcal enterotoxin A in complex with human MHC class II'''
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===Crystal structure of the D227A variant of Staphylococcal enterotoxin A in complex with human MHC class II===
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==Overview==
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Although the biological properties of staphylococcal enterotoxin A (SEA) have been well characterized, structural insights into the interaction between SEA and major histocompatibilty complex (MHC) class II have only been obtained by modeling. Here, the crystal structure of the D227A variant of SEA in complex with human MHC class II has been determined by X-ray crystallography. SEA(D227A) exclusively binds with its N-terminal domain to the alpha chain of HLA-DR1. The ability of one SEA molecule to crosslink two MHC molecules was modeled. It shows that this SEA molecule cannot interact with the T cell receptor (TCR) while a second SEA molecule interacts with MHC. Because of its relatively low toxicity, the D227A variant of SEA is used in tumor therapy.
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(as it appears on PubMed at http://www.pubmed.gov), where 12467569 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12467569}}
==About this Structure==
==About this Structure==
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[[Category: Walse, B.]]
[[Category: Walse, B.]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:06:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:33:36 2008''

Revision as of 18:33, 2 July 2008

Image:1lo5.png

Template:STRUCTURE 1lo5

Crystal structure of the D227A variant of Staphylococcal enterotoxin A in complex with human MHC class II

Template:ABSTRACT PUBMED 12467569

About this Structure

1LO5 is a Protein complex structure of sequences from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a SEA variant in complex with MHC class II reveals the ability of SEA to crosslink MHC molecules., Petersson K, Thunnissen M, Forsberg G, Walse B, Structure. 2002 Dec;10(12):1619-26. PMID:12467569

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